Daily Archives: 26 June, 2012

Reduce your risk of breast cancer

Taking exercise, even after the menopause, could cut women’s risk of breast cancer, but weight still matters.

We’ve heard, often, how important exercise is for our health. But how often do you need to do it, how hard must you exercise and for how long if you want to cut your cancer risk? A team led by Lauren McCullough at the University of North Carolina, Gillings School of Global Public Health looked at 1,504 women with breast cancer and 1,555 women who didn’t have the disease. The women covered a wide age range – from 20 to 98 years old – and were part of the Long Island Breast Cancer Study Project which is investigating possible environmental causes of breast cancer.

The results are encouraging for women of all ages, according to the study’s findings, published early online in CANCER, a journal of the American Cancer Society. Older and younger women – those who exercised before and during their postmenopausal years – had a lower risk of developing breast cancer. In fact the study says that these are the most critical years for reducing risk. And looking at all the women involved, from youngest to oldest, the study found that the most active had a 17% drop in risk compared with those who didn’t exercise.

“The observation of a reduced risk of breast cancer for women who engage in exercise after menopause is particularly encouraging given the late age of onset for breast cancer,” said Lauren McCullough. Breast cancer has been the most common cancer in the UK since 1997, and is more likely to affect older women. Between 2007 and 2009, 45% of breast cancer cases in the UK were diagnosed in women who were 65 and over.

Breast cancer

Breast cancer

There is one factor which is unchanged by being active: women who gained a significant amount of weight, especially after the menopause, had an increased risk of developing breast cancer, even if they exercised. This comes alongside the news from Cancer Research UK that even when overweight Britons know that their weight increases their risk of cancer, they struggle to summon the willpower to lose weight.


Being overweight or obese is one of the most important avoidable cancer risks. Scientists have estimated that the number of people who are overweight or obese in the UK could lead to around 19,000 cases of cancer a year.

Dr Harpal Kumar, Cancer Research UK’s chief executive, said: “Unless we tackle the obesity epidemic in the UK we risk cancer cases soaring. We understand that it can be extremely hard for people to maintain a healthy weight but keeping those extra pounds at bay would ultimately save your life.”

Sarah Williams, health information officer at Cancer Research UK, has reservations about the exercise study from North Carolina. This is because, rather than measuring things directly, the researchers asked women to remember how much exercise they had done outside work for every decade of their lives since their 20s, as well as how much they had weighed.

“There’s a substantial amount of evidence that breast cancer is less common among women who are more physically active. But just how active women need to be to reduce their risk is not yet clear,” she says. “While more research is being carried out, we recommend that women aim to do at least 30 minutes of exercise, five days a week, which will also help with keeping a healthy weight. Cutting down on alcohol and saturated fat can also reduce the risk of developing breast cancer.”

IVF and breast cancer concern

IVF treatment early in adulthood dramatically increases a woman’s chance of developing breast cancer, research suggests.

Women who started taking fertility drugs and went through IVF around their 24th birthday were found to have a 56 per cent greater chance of developing breast cancer than those in the same age group who went through treatments without IVF.

But there was no increased risk for women who started fertility treatments when they were about 40 years old, regardless of whether they had IVF or not, according to the Australian study.

The researchers said: ‘For younger women there is some cause for concern, because it appears that they may face an increased risk of breast cancer after IVF treatment.’

The findings were based on a study of more than 21,000 women and published in the journal Fertility and Sterility.

Study author Louise Stewart from the University of Western Australia said younger women might see an increased risk of breast cancer because they are exposed to higher levels of circulating estrogen during their cycles of IVF treatment.

However, she added: ‘I don’t think it’s a huge increased risk that you should worry or panic (about).’

The researchers collected information on 21,025 women between the ages of 20 and 40 who went through fertility treatment at the hospitals of Western Australia between 1983 and 2002.

They were able to piece together enough data to follow the women for some 16 years to see if they developed breast cancer.

IVF treatment

IVF treatment

Roughly 1.7 per cent of the 13,644 women who only used fertility drugs without IVF ended up developing breast cancer by the end of the study.

That figure was about two percent for women who used fertility drugs and underwent IVF – a difference that researchers said wasn’t statistically significant.

This changed when women were divided into different age groups, with women aged 24 about one-and-a-half times more likely to develop breast cancer if they had IVF alongside other fertility treatments.


However, Stewart said they couldn’t yet say that IVF was causing the increased cancer risk in younger women, as these women could be different in some significant way from those who only have other types of fertility treatment.

‘If for example, younger women who had IVF were more likely to have a specific cause of infertility, and this was related to an increased risk of breast cancer, then it would appear that IVF was related to breast cancer when in fact it was the type of infertility that was more common in women who had IVF,’ she said.

Linda Giudice, president-elect of the American Society of Reproductive Medicine, added: ‘The development of breast cancer is linked to estrogen exposure and the longer one is exposed, the greater the risk.

‘In an IVF cycle there is a short, but significant elevation in circulating estrogen, and whether this is linked to the observations found in the study is not clear at this time.’

The researchers said the study results would reassure women who start IVF treatment in their 30s and 40s.

However, they added: ‘Women should be aware that delivering their ?rst child late in reproductive life, whether assisted by IVF or not, is associated with an increased risk of breast cancer.’

Statistically, younger women have a greater chance of successfully having a baby following IVF.

They suggested a follow-up study of women who undergo a greater range of cycles to see if there’s a connection between IVF ‘dose’ and breast cancer rate.