Daily Archives: 1 July, 2012

Steroid levels linked to heart disease

Low levels of a naturally occurring steroid are associated with an increased risk of heart and blood-vessel disease in elderly men, a new study has found.

The steroid in question is dehydroepiandrosterone, or DHEA, which is secreted by the adrenal gland and circulates in blood mainly in a sulfated form, DHEA-S.

In other tissues, DHEA-S is converted into the sex hormones testosterone and estrogen.

Previous smaller studies had found an association between low DHEA-S levels and heart and blood-vessel, or cardiovascular, disease, although their results were inconclusive.

At this time, while we know that DHEA production decreases with age, the exact health effects of its decline are unclear.

In this large-scale study, investigators study found that elderly men with the lowest DHEA-S blood levels were significantly more likely than those with higher concentrations to develop cardiovascular-disease events within five years.

The increased risk persisted even after controlling for other influences, indicating that low DHEA-S levels are independently associated with a greater risk of disease.

The Heart

The Heart

“Our findings may be the result of DHEA-S being protective, or that lower DHEA-S level is a marker for poor general health,” Asa Tivesten, lead author of the study from the University of Gothenburg, Sweden, said.

“More research is needed to understand underlying mechanisms and to evaluate the potential benefits of hormone replacement,” Tivesten said.


For the study, investigators used an advanced laboratory technique to isolate, identify, and measure DHEA-S levels in the blood. During the five-year follow-up, they used nationwide medical registries to document 485 cases of cardiovascular disease among the study participants.

Patients included 2,416 men between the ages of 69 and 81 years. All were participants in the Osteoporotic Fractures in Men Sweden study, which is a long-term project designed to examine risk factors for a number of diseases.

According to Tivesten, it is important to note that this study’s findings only indicate that low DHEA-S levels may be related to a greater risk of cardiovascular disease.

“We cannot say that DHEA-S is protective because we have only studied an association,” she said.

“A potential practical implication is that established cardiovascular risk factors perhaps should be assessed and treated more aggressively in men with lower DHEA-S levels. However, this must be evaluated in future studies; today, DHEA-S level is not part of cardiovascular-risk assessment,” she added.

Coca-Cola colouring linked to cancer

Campaigners are calling for a ban on a colouring linked to cancer which has been found in Coca-Cola sold in Britain.

A chemical in the caramel colouring that gives the drink its distinctive colour has been at the centre of a health alert in the United States.

Coca-Cola has recently switched to a new manufacturing process in America to bring down the level of the suspect chemical, 4-methylimidazole (4-MI).

But this precaution has not yet been taken in other countries such as Britain, where its products are the nation’s biggest selling soft drinks with sales of £1.1billion a year.

The amount of 4-MI found in regular Coca-Cola cans sold in Britain was 135 micrograms – some 34 times higher than the 4mcg level in the US, according to research by the US group Center For Science In The Public Interest in partnership with Britain’s Children’s Food Campaign.

Health authorities in California are so concerned that they have passed a law that requires any can of drink containing a 4-MI reading of 30mcg or more to carry a health warning. If this safety assessment was applied in Britain, all cans of Coke would have to carry a warning.

The contaminant results from the industrial process, involving ammonia, that creates the caramel colouring. Chemical reactions between sugar and the ammonia result in the formation of 4-MI, which has been found to cause cancers in laboratory tests with mice and rats.

The results of the campaigners’ research are to be published in the International Journal Of Occupational And Environmental Health, and today they will write to British health ministers calling for an outright ban on the colouring.

Coca cola

Coca cola

Malcolm Clark, campaign co-ordinator at the lobby group, said: ‘Coca-Cola seems to be treating its UK consumers with disdain. The company should respect the health of all of its customers around the world, by using caramel colouring that is free of known cancer-causing chemicals.

‘The UK Government must regulate to protect public health from companies that aggressively market sugar-laden drinks that lead to obesity, diabetes and tooth decay.’

Manufacturers say it is possible to provide a caramel colour that is totally free of 4-MI, however it is four times more expensive.

The CSPI examined regular Coca-Cola from around the world. In the US the 4-MI level was 4mcg per 355ml. The figure was higher in every other country, from 56 in China to 267 in Brazil. Diet Coke and Coke Zero were not included, but earlier tests suggest they tend to have one third less of the contaminant than the standard drink.


The Office of Environmental Health Hazard Assessment in California, which made the warning labels law, said: ‘Studies published in 2007 by the federal government’s National Toxicology Program showed that long-term exposure to 4-MI resulted in increases in lung cancer in male and female mice.’

California’s experts suggest that regular consumption of 4-MI at its warning label level of 30mcg would cause cancer in one in 100,000 people over their lifetimes.

Coca-Cola strenuously denies there is any human health risk from 4-MI.

It said the decision to change the manufacturing process in the US, made public in March, was to avoid the need to apply ‘scientifically unfounded’ health warnings to cans and bottles.

The British arm of the company said it will change the caramel colouring used in its drinks in this country, but was unable to put a timescale on it.
It said: ‘We intend to expand the use of the reduced 4-MI caramel globally as this will allow us to streamline and simplify our supply chain, manufacturing, and distribution systems.’

The British Soft Drinks Association said there was no need to ban caramel colours containing 4-MI.

A spokesman said: ‘The 4-MI levels found in food and drink products pose no health or safety risks. Outside the state of California, no regulatory agency in the world considers the exposure of the public to 4-MI as present in caramels as an issue.’

The spokesman and Coke said food safety watchdogs in Britain and Europe have both decided the presence of 4-MI in caramel colouring is not a health concern.