Daily Archives: 13 September, 2012

Resveratrol and the elderly

Red wine isn’t usually associated with being steady on your feet.

But a ‘miracle ingredient’ in it could have that effect on pensioners, scientists claim.

They say that resveratrol, which is already credited with a host of health benefits from cutting cholesterol to warding off cancer, boosts balance and improves mobility.

In tests, old mice that were given the plant chemical for a few weeks became just as sprightly as young animals.

If resveratrol has similar effects on the human body, it could help prevent the painful falls and fractures from which many pensioners struggle to recover.

Falls are one of the leading causes of death in the over-75s, and half of elderly women die within two years of a fall.

The US researchers said: ‘Our study suggests that a natural compound like resveratrol, which can be obtained through dietary supplementation or diet itself, could actually decrease some of the motor deficiencies that are seen in our ageing population.

‘That would therefore increase an ageing person’s quality of life and decrease their risk of hospitalisation due to slips and falls.’ The researchers, from Duquesne University in Pittsburgh, fed resveratrol to young and old mice for eight weeks and regularly tested their ability to walk along a rodent-sized beam.

Red wine

Red wine

Initially, the older mice struggled but, over time, they became just as deft on their paws as the younger animals.

An American Chemical Society conference heard that it is not entirely clear how resveratrol, which is found in the grape skins that give red wine its colour, improves balance.

But rather than it strengthening bones or muscles, studies on cells in a dish suggest it helps ailing brain cells survive.


But don’t reach for the wine bottle just yet – you would fall over long before you drank the required amount.

Despite its potential in lab tests, resveratrol is so poorly absorbed by the human body that someone would have to drink several hundred glasses of wine a day to get the benefits enjoyed by the mice.

The researchers are now looking for compounds that work just as well but at much lower quantities.

They say that while there are medicines available to help improve balance and co-ordination in people with diseases such as Parkinson’s, there is nothing for otherwise healthy pensioners who are not as steady on their feet as they used to be.

Vitamin D may treat TB

Vitamin D can speed up recovery in tuberculosis (TB) patients, say researchers.

It suggests that the 19th century practice of sending patients to retreats to soak up the sun’s rays could have done some good.

The latest study found patients recovered more quickly from the infection lung disease if they combined antibiotics with exposure to sunlight.

The findings, from Queen Mary University, suggest high doses of the vitamin dampen down the body’s inflammatory response to infection, reducing damage to the lungs.

Study leader Adrian Martineau, said: ‘Sometimes these inflammatory responses can cause tissue damage leading to … cavities in the lung.

‘If we can help these cavities to heal more quickly, then patients should be infectious for a shorter period of time, and they may also suffer less lung damage.’

The researchers also said they think vitamin D’s ability to dampen inflammatory responses without interfering with the action of antibiotics suggests supplements might be useful for patients taking antibiotics for diseases like pneumonia, sepsis and other lung infections.

TB, which people in wealthier parts of the world often mistakenly believe to be a thing of the past, is proving a tough disease to beat. In 2010, it infected 8.8 million people worldwide and killed 1.4 million.

Drug-resistant cases of Tuberculosis are on the rise in the UK, according to figures released in July. In 2010, there were 342 cases which could not be dealt with by traditional antibiotics, while in 2011, this figure rose to 431.

Tuberculosis

Tuberculosis

The infection destroys lung tissue, causing patients to cough up the bacteria which then spreads through the air and can be inhaled by others.

In recent years, rates of drug-resistant TB have been spreading fast across the world, causing alarm among public health officials and prompting calls for more research into new and more effective treatments.


The researchers, whose study was published by the Proceedings of the National Academy of Sciences on Monday, split 95 TB patients who were on standard antibiotic treatment into two groups. For the first eight weeks of their treatment, 44 of them were also given high dose vitamin D, while the remaining 51 got placebos.

Anna Coussens from Britain’s National Institute for Medical Research measured signs of inflammation in blood samples to see what effect the vitamin D had on immune responses.

‘We found that a large number of these inflammatory markers fell further and faster in patients receiving vitamin D,’ she said.

The researchers also found that Mycobacterium tuberculosis, the bacteria that cause TB, cleared from the phlegm coughed up from deep in the lungs faster in patients on vitamin D, taking an average of 23 days to become undetectable under the microscope compared to 36 days in those on placebo.

Martineau said it was too early to recommend all TB patients take high-dose vitamin D alongside antibiotics, as more research with a larger group of patients was needed first.