Tag Archives: Ageing

Why women live longer than men

Women live longer than men partly because their immune systems age more slowly, a study suggests.

As the body’s defences weaken over time, men’s increased susceptibility to disease shortens their lifespans, say Japanese scientists.

Tests of immune function could give an indication of true biological age, they report in Immunity & Ageing journal.

The immune system protects the body from infection and cancer, but causes disease when not properly regulated.

The Japanese study set out to investigate the controversial question of whether age-related changes in the immune system could be responsible for the difference in average life expectancy between men and women.

Prof Katsuiku Hirokawa of the Tokyo Medical and Dental University and colleagues analysed blood samples from 356 healthy men and women aged between 20 and 90.

They measured levels of white blood cells and molecules called cytokines which interact with cells of the immune system to regulate the body’s response to disease.

In both sexes, the number of white blood cells per person declined with age as expected from previous studies.

However, closer examination revealed differences between men and women in two key components of the immune system – T-cells, which protect the body from infection, and B-cells, which secrete antibodies.

Why women live longer than men

Why women live longer than men

The rate of decline of most T-cell and B-cell lymphocytes was faster in men, while men also showed a more rapid age-related decline in two cytokines.

Two specific types of immune system cell that attack invaders – CD4 T-cells and natural killer cells – increased in number with age, with a higher rate of increase in women than in men.

The researchers believe a person’s immunological parameters could provide an indication of their true biological age.

“Age-related changes in various immunological parameters differ between men and women,” Prof Hirokawa and colleagues report in the online journal Immunity & Ageing.


“Our findings indicate that the slower rate of decline in these immunological parameters in women than that in men is consistent with the fact that women live longer than do men.”

Commenting on the study, Prof Tom Kirkwood of the Institute of Ageing and Health at the University of Newcastle upon Tyne, said the findings, while valuable, were not fundamentally surprising.

“It’s likely that the slower ageing in the immune system of women reflects a generally slower rate of intrinsic ageing, rather than that the immune system itself is setting the pace,” he told BBC News.

Dr Donald Palmer, senior lecturer in immunology at the Royal Veterinary College, said studies in mice had shown similar results.

Obesity and women’s heart risk

Both age and BMI are important factors in women’s heart disease, according to British researchers.

Getting older doesn’t necessarily mean you’ll get sick – in fact around half of all heart disease patients are under 65. But heart disease is more likely to prove fatal the older you are – so it’s good news that new research has found that a woman’s body mass index increases her risk of heart disease over and above her age-related risk. Why is this good news? Because unlike getting older, which is inevitable, you can actually do something about your BMI.

Researchers from the University of Oxford assessed data from more than one million women in England and Scotland for around ten years to calculate the link between BMI, age and risk of coronary heart disease.

They found that a 23% increase in heart disease risk with every five-point increase in BMI. (BMI was calculated as weight divided by height squared, or weight/height2.) This is the equivalent of ageing an extra two and a half years, in terms of heart disease risk.

One in 11 lean middle-aged women – ie those with a BMI of around 21 with little excess fat – were admitted to hospital for coronary heart disease or died from the disease between the ages of 55 and 74. For women with an average BMI of 34, this figure was one in six.

But the point, say the researchers, is that with every increase in BMI the figure rises and that, “This is seen not only in the heaviest women but also those who are not usually considered obese,” said lead study author Dr Dexter Canoy.

“Small changes in BMI, together with leading a healthy lifestyle by not smoking, avoiding excess alcohol consumption, and being physically active could potentially prevent the occurrence of CHD for a large number of people in the population.”

The heart

The heart

Do a little every day to reduce your BMI

If the idea of giving your diet a dramatic overhaul is too much to bear, make small changes every day. Over time these can amount to better results as you’re more likely to stick it and are also more likely to keep any weight you lose off rather than piling it back on again.


Simple everyday weight loss tips to try

Fats People often eat a lot more than they realise because it’s difficult to keep track. So ration yourself by pouring oil into a separate smaller container and limiting yourself to a specific amount each day or week. Similarly with butter, you can cut up a block of butter into daily ‘chunks’ – once you’ve eaten that amount for the day, you have to go without. You’ll soon get used to eating less.

Cheese Swap your mild Cheddar for mature. With the extra flavour you won’t need so much on a sandwich. Grate it too to maximise the sandwich flavour without adding extra cheese. You can also try lower-fat cheeses such as feta or cottage cheese.

Biscuits Make your own. There is no better way to get an excellent visual idea of exactly how much butter and sugar you’re eating on a daily basis. Once you see how many globs of butter are in those cookies you won’t be so tempted to eat them so quickly.

Sausages These are usually very high in fat so look for low-fat versions or add high-flavour versions such as chorizo or pepperoni and add them in chunks to casseroles with beans which means you won’t eat as much sausage and it will keep you fuller for longer without having to compromise on taste.

Grill Did you know you can grill eggs instead of fry them? Take half a roll or half a tomato (emptied of pips/flesh) and crack your egg inside then put under the grill until cooked.