Tag Archives: anti-oxidant

Luteolin fights colon cancer

A vital nutrient found in fruits and vegetables could help protect against colon cancer, which is the second most frequent cause of cancer-related deaths in the western world.

Luteolin is a flavonoid commonly found in fruit and vegetables. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain.

New research showed that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells.

Colon cancer cells have elevated levels of IGF-II compared to normal colon tissues. It is thought that this is part of the mechanism driving uncontrolled cell division and cancer growth.

Researchers from Korea showed that luteolin was able to block the secretion of IGF-II by colon cancer cells and within two hours decreased the amount of receptor (IGF-IR) precursor protein. Luteolin also reduced the amount of active receptor (measured by IGF-I dependent phosphorylation).

Fruit and vegetables

Fruit and vegetables

Luteolin inhibited the growth stimulatory effect of IGF-I and the team led by Prof Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer.


‘Luteolin reduced IGF-I-dependent activation of the cell signaling pathways PI3K, Akt, and ERK1/2 and CDC25c. Blocking these pathways stops cancer cells from dividing and leads to cell death,’ Prof Jung Han Yoon Park said.

‘Our study, showing that luteolin interferes with cell signaling in colon cancer cells, is a step forward in understanding how this flavonoid works.

‘A fuller understanding of the in vivo results is essential to determine how it might be developed into an effective chemopreventive agent,’ Prof Park added.

Crack open the walnuts

The festive season may be over, but there is at least one Christmas treat worth making a habit of eating throughout the year – walnuts.

Scientists have discovered they are the healthiest nuts to eat as they are loaded with antioxidants.

Snacking on as few as seven a day could help ward off disease and lower cholesterol, they claim.

Walnuts contain very high levels of polyphenol, an anti-oxidant which can protect the body from molecules which damage tissue.

Walnuts contained the most polyphenol out of a list of nine commonly eaten types of nuts, tests revealed.

Brazil nuts and pistachios were close behind, and cashews and hazelnuts had slightly lower levels of antioxidants.

Professor Joe Vinson, from the University of Scranton, Pennsylvania, said walnuts inhibit the growth of ‘bad’ cholesterol.

He said: ‘Walnuts rank above Brazil nuts, pistachios, pecans, peanuts, almonds, macadamias, cashews and hazelnuts.

‘Walnuts had the highest free and total polyphenols in both the combined and roasted samples’.

Despite the ‘superfood’ potential of walnuts, peanuts are the favourite with consumers and account for 45 per cent of the nuts bought in Europe.

Walnuts

Walnuts

The antioxidants in peanut butter were considerably lower than in roasted peanuts, the study found.

Dr Vinson said many people were put off by the seemingly high fat content of nuts, but they contained only polyunsaturated and monosaturated fats, rather than artery-clogging saturated fats.

He added: ‘Nuts are high in ?bre, low in saturated fats, high in bene?cial unsaturated fats, and very high in antioxidants.

‘Nuts are a nutritious snack providing both nutrients and bioactive antioxidants which provide significant health bene?ts.’

Advising consumers to keep the portion size small, Dr Vinson said it takes only about seven walnuts a day to get the potential health benefits.


The antioxidants found in raw walnuts were 15 times as powerful as Vitamin E, which can protect the body against damaging natural chemicals.

Roasted cashew nuts contained just double the level found in Vitamin E.

Nuts have long been promoted as a nutritious snack by health professionals.

Pecans contain around a sixth of the recommended daily allowance for zinc, which is vital for the functioning of white blood cells that fight bacteria and viruses, including colds and flu.

A couple of handfuls of shelled pistachios have more potassium than a banana. This can help control blood pressure, as part of a healthy diet, because potassium blunts the effects of salt.

And the brazil nut is the richest source of selenium, a nutrient that helps protect cells.

Higher selenium levels have been linked with a reduced risk of certain cancers such as bladder and prostate.