Tag Archives: Autoimmune diseases

Air toxins causing disease

Dust from wood manufacturing and recycling, and car exhaust emissions of the smallest carbon particles, are not covered by UK air pollution regulations.

Yet these “nano-toxins” have alarming health implications, causing serious ­autoimmune diseases like cancer, research has shown.

Graham Cliff, a retired particle physicist at Manchester University, said: “Wood dust contains silica, which is a known cancer-causing agent.

“If you are inhaling this in sufficient quantity, you’re going to suffer ill health. Diseases like cancer and dementia are now being attributed to air pollution.”

World Health Organisation guidelines for acceptable levels of wood dust in the air are two-and-a-half times lower than those in the UK.

Professor Cliff called for urgent action, likening the regulation shortfall to past attitudes on asbestos and smoking. He said: “Air pollution controls in the UK are inadequate.

“The smallest particles, which are the most dangerous, are not covered by current regulations. We don’t want the same situation as with asbestos and smoking, where it took 100 years to change thinking while people were dying.”

Last week traces of formaldehyde and arsenic were found in samples sent for tests by residents in three streets in Avonmouth in Bristol, where homes were blanketed with dust.

Pollution

Pollution

Elsewhere, families in 600 homes near a wood-processing plant in Mossley, Greater Manchester, have also suffered from respiratory problems like asthma, headaches and nosebleeds, which they blame on tiny dust particles.

The Sunday Express told of a cancer epidemic in a single street on the outskirts of Oxford earlier this month.


Sixteen people have died while two beat the disease in the past decade in Mickle Way, Forest Hill – far above the national average for cancer deaths of five cases for every 1,000 people.

Pets there have also been affected.

Resident Richard Sheldon-Battle, 64, whose wife Carol, 59, died from pancreatic cancer last month, said: “I cannot explain why so many people have been getting cancer in this street.

“It is the strangest thing. You might expect three or four people but not 18. It is like this street is cursed.”

The Department for Environment, Food and Rural Affairs said: “Pollution levels can fluctuate according to the weather.

“We want to keep improving air quality and reduce the impact it can have on health and the environment. Our air quality has improved in recent decades and is now generally very good.”

Junk food linked to autoimmune diseases

The modern diet of takeaways and microwave meals could be to blame for a sharp increase in conditions such as multiple sclerosis, say scientists.

Multiple sclerosis is one of a host of autoimmune diseases, including alopecia, asthma and eczema, where a person’s immune system attacks itself in error.

Now a team of scientists from Yale University in the U.S and the University of Erlangen-Nuremberg, in Germany, say salty diets could be partly to blame.

‘This study is the first to indicate that excess salt may be one of the environmental factors driving the increased incidence of autoimmune diseases,’ they said.

The team studied the role of T helper cells in the body. These activate and ‘help’ other cells to fight dangerous pathogens such as bacteria or viruses and battle infections.

Previous research suggests that a subset of these cells – known as Th17 cells – also play an important role in the development of autoimmune diseases.

In the latest study, scientists discovered that exposing these cells in a lab to a salt solution made them act more ‘aggressively.’

They found that mice fed a high-salt diet saw a dramatic increase in the number of Th17 cells in their nervous systems that promoted inflammation.

They were also more likely to develop a severe form of a disease associated with multiple sclerosis in humans.

The scientists then conducted a closer examination of these effects at a molecular level.

Junk food

Junk food

Laboratory tests revealed that salt exposure increased the levels of cytokines released by Th17 cells 10 times more than usual. Cytokines are proteins used to pass messages between cells.

Study co-author Ralf Linker, from the University of Erlangen-Nuremberg, said: ‘These findings are an important contribution to the understanding of multiple sclerosis and may offer new targets for a better treatment of the disease, for which at present there is no cure.’


MS is a neurological condition that affects 100,000 people in the UK.

It develops when the immune system mistakes the myelin that surrounds the nerve fibres in the brain and spinal cord for a foreign body.

It strips the myelin off the nerves fibres, which disrupts messages passed between the brain and body causing problems with speech, vision and balance.

Another of the study’s authors, Professor David Hafler, from Yale University, said that nature had clearly not intended for the immune system to attack its host body, so he expected that an external factor was playing a part.

He said: ‘These are not diseases of bad genes alone or diseases caused by the environment, but diseases of a bad interaction between genes and the environment.

‘Humans were genetically selected for conditions in sub-Saharan Africa, where there was no salt.

‘Today, Western diets all have high salt content and that has led to increase in hypertension and perhaps autoimmune disease as well.’

The team next plan to study the role that Th17 cells play in autoimmune conditions that affect the skin.

‘It would be interesting to find out if patients with psoriasis can alleviate their symptoms by reducing their salt intake,’ they said.

‘However, the development of autoimmune diseases is a very complex process which depends on many genetic and environmental factors.’

High-salt intake has already been linked to high blood pressure, and the Department of Health recommends that adults consume no more than 6g of salt a day.

However, in the UK, adults consume an average of between 9g and 12g of salt a day, with three-quarters hidden in everyday foods such as bread.