Tag Archives: b vitamin

Choline boosts the brain

This may be the first time you’ve heard of it, but diets rich in choline may help protect your brain from the affects of ageing.

The nutrient from the B vitamin family is found in foods like chicken, eggs and saltwater fish as well as legumes such as kidney beans.

Researchers at Boston University found people who got plenty of choline in their diets performed better on memory tests and were less likely to show brain changes associated with dementia.

The findings add to evidence that your lifetime diet may make a difference in how your brain ages, said senior researcher Dr Rhoda Au.

However, she cautioned against looking to any one nutrient as a magic bullet against dementia.

‘I think the message is that eating a healthy, balanced diet in mid-life is important,’ she said.

Previous research has found a Mediterranean-style diet, which includes fish, vegetables and olive oil, might have a protective effect.

For the latest study, Dr Au combed through the results from a long-running heart health survey.

Choline

Choline

Nearly 1,400 adults aged 36 to 83 answered dietary questionnaires between 1991 and 1995. Then, between 1998 and 2001, they underwent tests of memory and other cognitive abilities and had MRI brain scans.

The study found, men and women in the top quarter for choline intake performed better on the memory tests than those in the bottom quarter.

This held true even when factors including education and fat and calorie intake were taken into consideration.

People with higher choline intake at the outset were also less likely to show areas of ‘white-matter hyperintensity’ in their MRI brain scans.


Those age-related areas are thought to be a sign of blood vessel disease in the brain, which may signal a heightened risk of stroke or, eventually, dementia.

Dr Au said people who didn’t consume much choline would not notice an ‘appreciable difference’ day to day.

However, she said the findings suggest that people with lower choline intakes were more likely to be on a ‘pathway’ toward mental decline than their counterparts with higher intakes.

While the study does not conclusively prove choline protects the memory there is reason to believe that choline matters. The nutrient is a precursor to the brain chemical acetylcholine, which plays a key role in memory and other cognitive functions; low acetylcholine levels are associated with Alzheimer’s.

Dr Au concluded that more research was needed in this promising area.

Experts generally recommend that men get 550mg of choline per day, while women should get 425mg.

Folate Intake and colon cancer

Intake of high levels of folate may reduce colorectal cancer risk, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Folate is a water-soluble B vitamin that occurs naturally in food.

“We found that all forms and sources of folate were associated with lower risk of colorectal cancer,” said Victoria Stevens, PhD, of the American Cancer Society and lead author of this study. “The strongest association was with total folate, which suggests that total folate intake is the best measure to define exposure to this nutrient because it encompasses all forms and sources.” Total folate includes naturally occurring food folate and folic acid from fortified foods and dietary supplements.

A research team investigated the association between folate intake and colorectal cancer among 99,523 participants in the Cancer Prevention Study II Nutrition Cohort; a total of 1,023 participants were diagnosed with colorectal cancer between 1999 and 2007, a period entirely after folate fortification began. Neither higher nor lower risk was observed during the first two years of follow-up (1999 to 2001), while associations were statistically significantly inverse for the subsequent years (2002 to 2007).

Colon cancer

Colon cancer

The findings of this study add to the epidemiologic evidence that high folate intake reduces colorectal cancer incidence. Further, one important difference between the current study and previous studies was the separate assessment of natural folates and folic acid. Previous studies that discriminated between folates considered only the source (i.e., diet versus supplement) and not the chemical form.


The study also addressed concerns that the intake of high levels of folate frequently consumed in the U.S. — as a result of the recent increase in the use of folate-containing supplements and mandatory folate fortification of food — may actually increase risk of cancer. No increased risk of colorectal cancer was found for the highest intake levels, suggesting that the high levels of this vitamin consumed by significant numbers of Americans should not lead to increased incidence rates of this cancer in the population.

Folates are essential nutrients needed to make components used for functions required for normal cell growth, including DNA synthesis and repair. Because these processes are critical for cell growth and differentiation, the relationship between folate intake and cancer development has been investigated in several cancers, and most extensively in colorectal cancer.