Tag Archives: bowel

Donate your bowels

Doctors are calling for more Britons to agree to donate their bowel for transplant after they die.

Donor bowels can be used to cure severe cases of debilitating gut conditions such as Crohn’s disease and ulcerative colitis.

Yet, although donor cards may indicate an individual is willing to donate all their organs, families must consent to each transplant.

Family consent for bowel donation is lower than for other organs, including hearts, livers, kidneys and lungs.

While 99 per cent of donor families agree to kidneys and livers, only 79 per cent give the go-ahead for bowels.

Irritable bowel syndrome

Irritable bowel syndrome

‘Sadly, there seems to be limited awareness of bowel transplants, among donors’ families and transplant co-ordinators,’ says Darius Mirza, consultant transplant surgeon at Queen Elizabeth Hospital Birmingham and Birmingham Children’s Hospital, and author of new research on the subject.


‘Donor families have to give permission for each organ separately, and sometimes this can put extra strain on the co-ordinator asking for consent and the families who have to decide at a time of immense grief,’ says Mr Mirza.

‘Families give consent more readily for the transplant organs that are better known.’

About 20 bowel transplants were carried out in the UK last year.

Mr Mirza says: ‘The operation is life-changing, especially for young children born without a working bowel.’

Bowel cancer faulty genes discovery

Researchers from Oxford University and The Institute of Cancer Research, London, scanned the genes of 20 people from families with a strong history of bowel cancer.

They found everyone who had a faulty gene designated as either “POLE” or “POLD1” developed bowel cancer or had a precancerous growth in the bowel, according to findings published in the journal Nature Genetics.

To confirm their findings they then looked for the faults in almost 4,000 people with bowel cancer and 6,700 without the disease, in work funded by Cancer Research UK.

Neither of the faults were found in people without bowel cancer, while 12 people with the POLE gene were found in the bowel cancer group and one person had a POLD1 gene fault.

POLE and POLD1 are involved in scanning and repairing damage to DNA, removing incorrect sequences from the DNA chain.

Irritable bowel syndrome

Irritable bowel syndrome

Without the genes, affected individuals build up damage in their DNA which can cause bowel cancer.

The POLD1 fault was also found to increase the risk of getting womb cancer and possibly brain tumours with seven people in the study being diagnosed with womb cancer and one developing two brain tumours.


Professor Richard Houlston from The Institute of Cancer Research said: “Uncovering gene faults like these two is extremely important, as inherited susceptibility plays a role in the development of about a third of all cases of colorectal cancer.

“This is one of the most important discoveries in bowel cancer genetics in years. It should allow us to manage families affected by inherited bowel cancer much more effectively, and it offers new clues for the prevention or treatment of all forms of the disease.”