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Antibiotic dangers

Taking antibiotics can mean you become more prone to secondary infections, but why, and what can be done about it?

Even if you’ve been blessed with the constitution of an ox, you’re likely to have been handed a prescription for antibiotics at some stage in your life. And you’ve probably felt better for taking them. But going on a lengthy course of broad-spectrum antibiotics can bring problems of its own. While the initial problem may clear up, taking the antibiotics can mean you become more prone to severe secondary infections.

For a long time scientists have been wondering why taking a medication that knocks one infection out, invites others in. Now research from the University of Pennsylvania School of Medicine may have given us an explanation.

The research has shown that the good bacteria in the gut keep the immune system at the ready to fight off infection from invading pathogenic or disease-causing bacteria. For senior author Jeffrey Weiser, MD, professor of Microbiology and Pediatrics, it’s rather like starting a car: It’s much easier to start moving if a car is idling than if its engine is cold. In the same way, if the immune system is already warmed up, it can better cope with the bad bacterial invaders. The implication of these initial findings in animals, he says, is that prolonged antibiotic use in humans may effectively throttle down the immune system, so that it is no longer working at peak levels.

Antibiotics

Antibiotics

It’s down to white blood cells known as neutrophils, and how well they’re working. “Neutrophils are being primed by innate bacterial signals, so they are ready to go if a microbe invades the body,” Jeffrey Weiser explains. “They are sort of ‘idling’, and the baseline system is already turned on.”

“One of the complications of antibiotic therapy is secondary infection,” says Jeffrey Weiser . “This is a huge problem in hospitals, but there hasn’t been a mechanistic understanding of how that occurs. We suggest that if the immune system is on idle, and you treat someone with broad-spectrum antibiotics, then you turn the system off. The system is deprimed and will be less efficient at responding quickly to new infections.” The study was carried out with mice, so further research needs to be done, but findings so far show that it may be possible to find a way of giving antibiotics to humans with just the beneficial effects and not the drawbacks.


So how do you keep the immune system ready to fight off infection if you have to take antibiotics? The first step is to live well before you need medical treatment. “Try to stay as healthy as possible,” says dietitian Sian Porter, spokesperson for the British Dietetic Association (BDA). “Stay physically active, get enough sleep and have a good diet. If you’re eating plenty of different types of fruit and vegetables, oily fish, whole grains and calcium, this should help to keep you healthy.”

Sometimes though, even this isn’t enough to keep us well and antibiotic-free. Elizabeth Weichselbaum, of the British Nutrition Foundation, has carried out a study of research into probiotics and how well they work. Probiotics are designed to provide us with good bacteria and help recreate balance in the gastro-intestinal tract.

Eat your berries

THEY have been described as nature’s superfood and now is the perfect time to stock up on berries.

Whether you buy them in the supermarket or forage in the hedgerows berries are a wonderful source of nutrients. What’s more they are easy to prepare and naturally low in calories and fat.

Home-grown berries are available right through the summer into late autumn and thanks to the warm spring this season there’s a record crop.

Plant compounds found in berries could protect against many forms of cancer. It’s not clear exactly how they work but they’re thought to keep the body’s cells healthy. Some fruits and berries contain higher concentrations of these compounds than others and a simple test is to look at the colour.

Dense, dark colours are a good sign that berries are bursting with goodness. Blackberries, blueberries and raspberries all fall into this category.

Some studies show that raspberries contain 10 times more of these compounds than tomatoes and broccoli. Berries are also a source of fibre, which is important for general health and the gut.

The natural sugars found in berries make them a great alternative to biscuits, cakes and other sweet snacks. Bridget Benelam, a nutrition scientist at the British Nutrition Foundation, says: “A slice of cake contains about 10 times more calories than the equivalent weight of berries. Berries are also virtually fat-free.”

Berries

Berries

Try not to add sugar to naturally sweet berries such as strawberries and raspberries. You can also use them as an alternative to sugar in cooking. Sprinkle a handful of blueberries on your bowl of cereal or add berries to a salad.

In addition to containing plant compounds it’s thought that blueberries may help lower cholesterol and contain a substance which can prevent bladder infections. When shopping for jams give sugar-free versions a try but watch out for berry drinks with added sugar, such as cranberry juice. Too much sugar can cause tooth decay.

Nothing beats the taste and texture of freshly picked berries but the good news is that they remain healthy after they’ve been frozen.

Berries are at their best when they’ve been freshly harvested. Ways of ensuring that your berries are at their peak is to buy local or visit a fruit farm where you can pick your own.

It’s not only fun and usually cheaper than a supermarket but also a good way of encouraging children to eat more fruit. They’re more likely to do that if they have harvested the berries themselves and become involved in the food’s journey from field to meal table.

Most berries tend to become a bit mushy when they are defrosted but that doesn’t affect their goodness so you can pop a few portions in the freezer when they are in season for use later on.


Berries in all forms can be mixed together to make great tasting juices or added to milk, bananas and yogurt to produce smoothies.

Bridget adds: “Berries do lose some of their goodness if dried but are still a healthy option. Frozen berries are great because it’s usually done soon after harvesting.”

One of the best berries, the humble blackberry, can be gathered free by foraging in hedgerows. Blackberries contain among the best levels of healthy plant compounds and British varieties are available until November.

Compounds in the common British blackcurrant could help prevent Alzheimer’s disease, a study suggests. Research in the Journal Of The Science Of Food And Agriculture found they may help block the cell damage which leads to Alzheimer’s disease.

Eating berries won’t cure dementia but the researchers think they can help prevent it.

Most berries contain vitamin C but the blackcurrant is tops, followed in second place by the strawberry.

Blackcurrants contain about 10 times more vitamin C than many other berries. We need vitamin C for a healthy immune system.