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Vitamin C and dementia

A GLASS of orange juice a day could be the key to managing Alzheimer’s disease.

Scientists have found that vitamin C can help reverse the build-up of toxic proteins which form into harmful plaques in the brains of sufferers.

Researchers at Lund University in Sweden hope their discovery can be used to slow the progress of the disease in those who already have it.

Katrin Mani, reader in molecular medicine at the university, said: “When we treated brain tissue from mice that had Alzheimer’s disease with vitamin C, the toxic protein aggregates were dissolved.

Vitamin C

Vitamin C

The notion that vitamin C can have a positive effect on Alzheimer’s disease is controversial but our results open up new opportunities for research and the possibilities offered by vitamin C.”

Ms Mani added that while vitamin C is in fresh fruit it can be absorbed in larger quantities from fruit juice.


She said: “Vitamin C is not a drug and having an extra daily glass of orange juice would do no harm.”

At least 750,000 people in the UK have Alzheimer’s, a number which is expected to double by 2050. There is no cure or effective treatment and the cost to the NHS is predicted to rise to £50billion in the next 30 years.

Atherosclerosis link to Alzheimer’s

Clogged arteries or atherosclerosis that causes heart disease can bring on dementia by restricting blood flow to the brain.

Dementia includes difficulty with thinking, reasoning and memory, and can be caused by vascular disease (related to blood vessels), Alzheimer’s disease, a combination of both and other causes.

Atherosclerosis is a build-up of plaque in the arteries linked with elevated blood pressure, cholesterol, smoking and other risk factors. Alzheimer’s is a progressive brain disorder that destroys brain cells.

When clogged arteries restrict or blocks blood flow to the brain, it is called cerebrovascular disease, which can result in vascular cognitive impairment, reports Stroke: Journal of the American Heart Association.

“We have learned that cerebrovascular disease and Alzheimer’s disease may work together to cause cognitive impairment and the mixed disorder may be the most common type of dementia in older people,” said Philip B. Gorelick.

Atherosclerosis

Atherosclerosis

The prevalence of dementia increases with advancing age and affects about 30 percent of people over 80 years of age, added Gorelick, director of the Centre for Stroke Research at the University of Illinois College of Medicine, Chicago, according to its statement.

Physical activity, healthy diet, healthy body weight, tobacco avoidance as well as blood pressure and cholesterol management could significantly help many people maintain their mental abilities as they age.


“Generally speaking, what is good for the heart is good for the brain,” Gorelick said.

“Although it is not definitely proven yet, treatment or prevention of major risk factors for stroke and heart disease may prove to also preserve cognitive function with age.”