Tag Archives: cardiovascular

Tea and coffee ward off stroke risk

When it comes to choosing between tea or coffee, the best answer may be to opt for both.

Scientists have found that individuals who enjoy a daily cup of coffee were 20 per cent less likely to have a stroke compared to those who shunned the drink.

And those that drank at least four cups of green tea a day also benefitted from a similarly reduced stroke risk.

But as the popular beverages are thought to protect against the often fatal condition in different ways, the study suggests regularly drinking both could provide the greatest benefit.

Researchers looked at the drinking habits of almost 84,000 Japanese adults over a 13-year period.

‘This is the first large-scale study to examine the combined effects of both green tea and coffee on stroke risks,’ said lead author Dr Yoshihiro Kokubo, from Japan’s National Cerebral and Cardiovascular Centre.

‘You may make a small but positive lifestyle change to help lower the risk of stroke by adding daily green tea to your diet.’

The study, published in American Heart Association’s journal Stroke, found that the greater amounts of coffee or green tea consumed, the lower their stroke risk.

The report found that ‘combination of higher green tea and coffee consumptions contributed to the reduced risk of stroke as an interaction effect for each other.’

But even in lower quantities, green tea helped protect against the condition, with those drinking between two to three cups seeing their chance of a stroke fall by 14 per cent.

Green tea

Green tea

Participants in the study were 45 to 74 years old and were free from cancer and cardiovascular disease, and all the findings were adjusted to take into account age, sex and lifestyle factors like smoking, alcohol, weight, and exercise.


Green tea drinkers in the study were more likely to exercise compared to non-drinkers, while coffee drinkers tended to be younger, and were more likely to smoke and take exercise.

Although it is unclear how green tea affects stroke risks, scientists believe a compounds known as catechins may provide some protection to blood vessels.

Several chemicals in coffee are believed to provide a boost to health, including caffeine and chlorogenic acid, which researchers suggest could help cut stroke risks by lowering the chances of developing type 2 diabetes.

Both drinks also helped to protect from the risk of heart attacks, according to the researchers.

‘The regular action of drinking tea, coffee, largely benefits cardiovascular health because it partly keeps blood clots from forming,’ said Dr Kokubo.’

Research last year found the more coffee you drink, the less likely you are to die from a number of different ailments, including heart disease, respiratory disease, diabetes and infections – but not cancer.

Researchers at the National Cancer Institute, National Institutes of Health, Maryland, said they could not establish whether coffee was the cause of a lowered risk of death, but there was definitely a link.

The research, published in The New England Journal of Medicine, followed 229,000 men and 173,000 women aged between 50 and 71, between 1995 and 2008. Participants were classified according to how much coffee they drank.

There were 52,000 deaths during the period, with an ‘inverse association’ between coffee consumption and death. This means the greater the amount of coffee participants drank, the lower their risk of dying during the study.

Calls to ban diclofenac

Safer alternatives exist to diclofenac, say researchers at the Barts and the London School of Medicine and Dentistry, who want it banned worldwide.

Diclofenac, like ibuprofen, is a non-steroidal anti-inflammatory drug or ‘NSAID’. It is often prescribed after surgery and to combat arthritic pain, when ibuprofen is not strong enough.

It can also be purchased over the counter at a pharmacy without a prescription, for example in the branded form of Voltarol Pain-eze tablets.

But two years ago the Barts researchers found that it was linked with a 40 per cent increased risk of heart attack and stroke.

That analysis crystallised the fears of many doctors, who have raised concerns about the drug for years.

Another study, also published in 2011, indicated diclofenac raised the risk of dying from heart attack or stroke four-fold.

Writing in the journal PLoS Medicine Dr Patricia McGettigan, who led the 2011 study, said drugs regulators needed to take action now.

She said: “The regulators need to look at medicine like this on the basis that the evidence that it causes harm has been known for years but its sale and prescription patterns in England are only slowly drifting down.

“If it is not going to change appropriately then the regulators need to act, particularly when there is a safer alternative available.”

About five million prescriptions are made for diclofenac every year, according to official data. Although many take it regularly, lots of people take it as a ‘one off’, meaning it is likely that well over a million take it every year. The risks are highest in those who take it regularly.

Dr McGettigan, who has trained as both a pharmacist and doctor, noted the increased risk from diclofenac was not much less that from another drug, which was withdrawn in 2004. Vioxx, an arthritis drug, was found to raise the chance of heart attack and stroke by 45 per cent.

Diclofenac still appears on the World Health Organisation’s list of “essential medicines” in 74 countries, according to Dr McGettigan and her colleague David Henry, chief executive of the Institute for Clinical Evaluative Sciences at the University of Toronto, who contributed to the study.

Professor Henry said: “Given the availability of safer alternatives, diclofenac should be de-listed from national essential medicines lists.”

Dr McGettigan added: “Diclofenac has no advantage in terms of gastrointestinal safety and it has a clear cardiovascular disadvantage,” she said.

“Because it’s been around for so long people have become familiar with it and almost don’t believe it could have a side effect like this.

Diclofenac

Diclofenac

“There are strong arguments to revoke its marketing authorisations globally.”

A spokesman for the UK drugs regulator, the Medicines and Healthcare Products Regulatory Agency (MHRA), said diclofenac was “an extremely important NSAID”.


He said: “For most patients the risks of side-effects are outweighed by the benefits these drugs bring in managing pain.”

He continued: “The MHRA has carefully reviewed the safety profile of diclofenac as new data becomes available. This has resulted in updates to information for healthcare professionals and patients, and numerous communications to ensure that any risk to patients is minimised.

“Our advice remains that these medicines should be used for the shortest time necessary and at the lowest dose possible to control symptoms.”

A European review, instigated by the MHRA, was currently taking place, he added.

Maureen Talbot, senior cardiac nurse at the British Heart Foundation, urged caution when prescribing NSAIDs but did not say diclofenac should be banned.

She said: “The risks associated with non-steroidal anti-inflammatory painkillers, which include diclofenac, have been known for some years and they should always be prescribed with caution.

“Anyone taking these painkillers should be made aware of both their risks, especially of cardiovascular disease and internal bleeding, and benefits in treating debilitating pain such as that caused by arthritis.

“If you are taking these powerful drugs and are worried, discuss your concerns with your GP or pharmacist who will be able to help you decide whether the benefits outweigh the risks.”