Tag Archives: chronic obstructive pulmonary disease

New asthma drug – Tiotropium

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A DRUG that reduces the number of asthma attacks by more than a fifth could offer hope to hundreds of thousands of patients who suffer from the most severe form of the debilitating lung disease.

Trials on nearly 1,000 people with uncontrolled asthma showed the drug tiotropium taken through a mist inhaler opened constricted airways and appeared to improve lung function.

Even those with severe asthma saw the number of attacks cut by 21 per cent and the time between attacks extended by a third.

The drug – already licensed for chronic obstructive pulmonary disease, which usually affects smokers – could be available on the NHS in a few years.

Five million Britons suffer from asthma, with 250,000 diagnosed with a severe form. On average, three patients die each day during an attack.

Asthma

Asthma

The disease is usually treated with a steroid inhaler or tablets, which can have serious side effects including skin thinning, weight gain and osteoporosis.


Neil Churchill, of charity Asthma UK, said: ‘People with asthma are anxious about what steroids are doing to them, particularly if they have to take them long term. Having another tool will be useful.’

And researcher Dr Richard Russell, a lung specialist at Wexham Park Hospital in Berkshire, said the drug could be a ‘new weapon in our armoury.’

Vitamin C and air pollution

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A diet rich in fruits and veggies may lessen the harmful effects of air pollution for people suffering from chronic lung diseases, researchers suggest.

Researchers looked at London hospital patients with asthma or chronic obstructive pulmonary disease (COPD), and found that those with low levels of vitamin C had an increased risk of breathing problems on days when outdoor air pollution levels were high.

“This study adds to a small but growing body of evidence that the effects of air pollution might be modified by antioxidants,” said Michael Brauer, an environmental health scientist at the University of British Columbia in Canada.

Antioxidants, such as vitamin C, may protect the body from harmful molecules called free radicals that damage cells. Free radicals can form when air pollution enters the lungs, and evidence suggests they play a role in heart disease, cancer and even respiratory ailments.

Antioxidants can bind to free radicals, counteracting them before they damage cells.

Pollution

Pollution

In the new study, researchers at Imperial College in London looked at more than 200 patients admitted to the hospital for asthma or COPD, along with the levels of air pollution on the days before and after they entered the hospital. The majority of patients were between ages 54 and 74, though some were as young as 18. Many of them were former smokers.

Specifically, the researchers looked at levels of “course particulate matter,” which is produced largely through the combustion of fossil fuels.


Results showed that with every increase in course particulate matter of 10 micrograms per cubic meter (mcg/m3), there was a 35 percent increased risk of hospital admission for people with asthma or COPD.

However, the risk of admission was 1.2 times greater among people with low levels of vitamin C.

Study researcher Cristina Canova said, “the protective effect of vitamin C was still present after excluding smokers and elderly subjects, implying that the effect of this antioxidant was not explained by smoking or age.” However, the study noted that smokers and older people tend to have lower levels of many nutrients than nonsmokers.