Blueberries may help combat dementia and alzheimers

Snacking on blueberries from middle age could prevent dementia developing decades later, scientists say.

Experts told a major US conference that a compound in the berries may strengthen the brain’s defences against Alzheimer’s.

In the absence of effective drugs, a nutritional option ‘represents a potentially potent approach to mitigate risk for late-life dementia’, they said.

Alzheimer’s and other forms of dementia affect some 850,000 Britons and cost the economy £26billion a year.

With the search for new medicines largely fruitless, despite hundreds of drug trials and billions of pounds of funding, some experts believe more emphasis should be placed on the benefits of a healthy diet.

Candidates include the humble blueberry, a ‘superfood’ already credited with lowering the risk of heart disease and cancer.

University of Cincinnati researcher Robert Krikorian (CORR) studied 47 men and women aged 68-plus who had been diagnosed with mild cognitive impairment.

The term covers the slight memory lapses that often, although not always, develop into full-blown dementia.

All were given a placebo powder or one made of freeze-dried blueberries to take once a day for four months.

The blueberry powder been specially made for the study, and one sachet contained the equivalent of a small teacupful of berries.

The volunteers were also put through a battery of mental tests at the study’s start and end, with a focus on memory and thinking skills that are eroded by dementia.

The results showed that the berries seemed to give the ageing brain a boost.

Dr Krikorian said: ‘There was a significant improvement in cognitive function in those who had the blueberry powder, compared with those who took the placebo.’

In addition scans showed the brain was more active in those who had taken the blueberry powder.

The researcher believes the benefits are due to anthocyanins, the plant chemicals that give the berries their deep blue/purple colour.

Blueberries
Blueberries

They are thought to act on the brain in various ways, including boosting blood flow, cutting inflammation, and enhancing the passage of information between cells.

The chemicals may also boost cells’ defences, an American Chemical Society conference heard.

In a second study of people who hadn’t been diagnosed with any memory problems, but simply felt they were becoming more forgetful, the berries also helped boost cognition, although to a lesser extent.




When previous research is factored in, Dr Krikorian, who received funding from the US government, as well as from berry growers, says all the evidence points to blueberries having the potential to prevent the onset of dementia.

He said: ‘Our findings corroborate those of previous animal studies and preliminary human studies, adding further support to the notion that blueberries can have a real benefit in improving memory and cognitive function in older adults.’

He now wants to study people in their 50s and early 60s whose weight, blood pressure or other medical condition puts them at higher than usual risk of Alzheimer’s.

But, in the meantime, he advises healthy adults to stock up on blueberries.

And with research suggesting Alzheimer’s may eat away at the brain for decades before symptoms start to show, he says it is important to protect the brain from middle-age.

Dr Krikorian said: ‘I believe that berry supplementation and, in particular, blueberry supplementation, may reduce the risk for late-life cognitive decline.

‘The minimum dose is not clear but data suggest that taking blueberries several times a week should be beneficial.’

Indigestion drugs linked to Alzheimers

A popular type of indigestion and heartburn pill taken by millions of Britons could increase the risk of dementia by 44 per cent, according to a study.

Researchers found that people aged 75 or older who regularly take proton pump inhibitors (PPIs), a group of drugs that includes Pantoloc Control and Zanprol, had an increased risk of the disease.

The drugs work by lowering the amount of acid produced by the stomach and are prescribed to millions of Britons every year for heartburn, acid reflux or peptic ulcers.

The German study was based on the insurance data of 74,000 people over 75 from 2004 to 2011.

It identified 29,510 patients who developed dementia during the study period. But among the 2,950 of the total who regularly took PPIs, a greater proportion had dementia, giving them a 44 per cent increased risk compared with those who had not taken PPIs, the Daily Mail reported.

The scientists, from the German Centre for Neurodegenerative Diseases in Bonn, acknowledged that they had been unable to identify different risk factors for dementia.

Dementia
Dementia

They wrote in the journal JAMA Neurology: “The present study can only provide a statistical association between PPI use and risk of dementia. The possible underlying causal biological mechanism has to be explored in future studies.

“The avoidance of PPI medication may contribute to the prevention of dementia.”




Separate US research by Stanford University last year found a possible link between PPIs and heart attacks.

Dr Laura Phipps of Alzheimer’s Research UK said: “This study doesn’t tell us definitively that the drugs directly cause the condition. The next step will be to investigate the possible reasons for this link.”

John Smith, of the Proprietary Association of Great Britain, which represents firms making over-the-counter drugs, said: “All over-the-counter medicines have been approved by the Medicines and Healthcare Products Regulatory Agency and are rigorously assessed for safety and efficacy.

“Once on the market, their safety is continually monitored in light of any emerging evidence. Those who may be concerned should speak to their GP or pharmacist before taking any medicine.”