Tag Archives: disease diabetes

Obesity link to dementia

According to research published in the Archives of Neurology a hormone produced as a result of visceral (abdominal) fat, is believed to increase a person’s risk of developing all-cause dementia and Alzheimer’s disease.

The hormone known as adiponectin is derived from visceral fat and sensitizes the body to insulin, is instrumental in metabolising lipids and glucose and has anti-inflammatory properties.

The researchers from the Human Nutrition Research Centre on Aging at Boston’s Tufts University looked at various compounds found in patient plasma documented in the Framingham Heart Study, which was conducted between 1985 and 1988. Among these compounds was adiponectin.

The study included 840 patients of which 541 were women with a median age of 76 years. These patients were checked on an average of 13 years afterwards, and during this time 159 of them developed dementia.

Alzheimer’s

Alzheimer’s

Their findings showed that, women in particular, with elevated levels of adiponectin appeared to have an increased risk of all-cause dementia and Alzheimer’s disease.


“Surprisingly, a higher adiponectin level was found to be a predictor of all-cause and vascular mortality. In concurrence with the mortality findings, the current investigation shows that an elevated adiponectin level is also an independent predictor for all-cause dementia and AD in women,” says the authors of the study.

Visceral obesity is more than just an annoying muffin top or ‘beer belly’, it surrounds the internal organs, and has been linked to many other health problems such as heart disease, diabetes and some types of cancers. It can also cause inflammation of the artery walls and colon. Luckily a healthy diet and the right exercise have been shown to effectively reduce levels of this fat in the body.

Oxidative stress effects on the body

Anti-oxidants play a critical role in protecting cells but could also damage them or cause their deaths if they are malfunctioning, a study reveals.

This damage known as oxidative stress is believed to be tied with Alzheimer’s, Parkinson’s disease, coronary heart disease, diabetes and is also implicated in aging.

For the first time, scientists of the German Cancer Research Centre (known as the Deutsches Krebsforschungszentrum or simply DKFZ in German) have been able to directly observe oxidative changes in a living organism.

Basing their study on fruit flies, researchers found no evidence that the life span is limited by the production of harmful oxidants, according to a statement by DKFZ.

“However, up to now, nobody was able to directly observe oxidative changes in a living organism and certainly not how they are connected with disease processes,” said Tobias Dick, researcher at the DKFZ.

Alzheimer's

Alzheimer's

“There were only fairly unspecific or indirect methods of detecting which oxidative processes are really taking place in an organism,” said Dick.

For the first time, Tobias Dick and his co-workers have been able to observe these processes in a living animal. Jointly with Aurelio Teleman (also of DKFZ), they introduced genes for biosensors into the genetic material of fruit flies.


These biosensors are specific for various oxidants and indicate the oxidative status of each cell by emitting a light signal — in realtime, in the whole organism and across the entire life span.

Many scientists have assumed that the aging process is associated with a general increase in oxidants throughout the body.

However, this was not confirmed by the observations made by the investigators across the entire life span of the adult animals.

Even though comprehensive studies have failed to provide proof until the present day, anti-oxidants are often advertised as a protection against oxidative stress and thus health-promoting.