Tag Archives: hydrogen peroxide

Men at higher risk of skin cancer

Lower levels of an important skin antioxidant may be the reason behind males being more vulnerable to skin cancer than women, a new study has suggested.

Researchers at The Ohio State University Comprehensive Cancer Center have found that male mice had lower levels of an important skin antioxidant than female mice and higher levels of certain cancer-linked inflammatory cells.

The antioxidant, a protein called catalase, inhibits skin cancer by mopping up hydrogen peroxide and other DNA-damaging reactive-oxygen compounds that form during exposure to ultraviolet B light (UVB), a common source of sunburn and cancer-causing skin damage.

“The findings suggest that women may have more natural antioxidant protection in the skin than men,” said study co-leaders Gregory Lesinski and Tatiana Oberyszyn.

“As a result, men may be more susceptible to oxidative stress in the skin, which may raise the risk of skin cancer in men compared to women,” said Lesinski.

Skin cancer

Skin cancer

Lesinski, Oberyszyn, Sullivan and their colleagues conducted the study using a strain of hairless mice that develops squamous cell carcinoma of the skin – the second most common skin cancer in humans – when exposed to UVB.

The investigators also found that treating mice with topical catalase inhibited the migration of the suppressor cells into UVB-exposed skin, suggesting that the influx of these cells in males might be due to the relatively lower skin-catalase activity.

In fact, male mice with UVB-induced skin tumours had 55 percent more of the suppressor cells in the skin than did their female counterparts.


“This is the first report to our knowledge of a sex discrepancy in this group of inflammatory cells in tumour-bearing mice, and it suggests that our findings might translate to other types of cancer,” said Oberyszyn, associate professor of pathology.

“Men face a higher risk of numerous types of cancers, and relatively higher levels of inflammatory myeloid cells might contribute to this susceptibility,” Oberyszyn added.

The research has been published online in the Journal of Investigative Dermatology.

Watercress cuts cancer risk

Eating watercress regularly could help cut the chances of developing cancer, research suggests.

The University of Ulster work suggests it cuts DNA damage to white blood cells – considered to be an important trigger in the development of cancer.

Watercress appears to raise levels of beneficial compounds, and cut levels of harmful compounds in the blood.

The study is funded by the Watercress Alliance, but is published in the American Journal of Clinical Nutrition.

Papers published in this journal are checked by other scientists before they are published.

During the study 60 healthy volunteers, including 30 smokers, ate an 85g bag of fresh watercress every day for eight weeks.

The researchers carried out tests before and after this change in diet.

They found that DNA damage to white blood cells was cut by 22.9%.

The cells were also more able to protect themselves from the damaging effects of particles called free radicals.

When cell samples were exposed to hydrogen peroxide, which generates large numbers of free radicals, damage levels were 9.4% lower than would normally be expected.

Watercress

Watercress

Blood levels of antioxidant compounds, such as lutein and beta-carotene, which can combat the effect of free radicals were raised.

In contrast, levels of potentially harmful triglycerides were cut by an average of 10%.

The beneficial changes were greatest among the smokers – who were found to have significantly lower levels of antixoidant compounds at the start of the study.

Previous studies have suggested eating increased amounts of cruciferous vegetables like watercress is linked to a reduced risk of a number of cancers.

One study on human colon cancer cells showed watercress extract cut DNA damage in the cells, and helped control their growth and spread.

But lead researcher Professor Ian Rowland, who is now at the University of Reading, said the latest study was important because it involved people eating watercress in easily achievable amounts, rather than lab tests on vegetable extracts.

He said: “Blood cell DNA damage is an indicator of whole body cancer risk, and the results support the theory that consumption of watercress is linked to an overall reduced risk of cancer at various sites in the body.”


Lynn Faulds Wood, the former BBC Watchdog presenter who set up Lynn’s Bowel Cancer Campaign after successfully fighting bowel cancer, said: “It’s great to know there are simple things that people can do – like eating watercress – which could help them avoid getting cancers like bowel cancer in the future.”

Claire MacEvilly, a nutritionist at MRC Human Nutrition Research, said: “What is interesting to us is that the scientists have been able to quantify the actual amount of watercress needed to reduce the risk of developing cancer and that the recommended amount is achievable in a typical day.

“Questions still remain about how the compounds in vegetables work in the body to reduce the risk of cancer but the results of this study add to the body of evidence that eating fruit and vegetables is important in the prevention of this series disease.”

Dr Anthea Martin, of the charity Cancer Research UK, said larger studies were needed to determine whether the effects of watercress on cells seen by the researchers translate into a decreased risk of developing cancer.

Professor Karol Sikora, cancer expert at Imperial College London, pointed out that all fruits and vegetables affect DNA damage, hence the recommendation that people eat five portions a day.