A new study has identified 71 additional genetic associations for inflammatory bowel disease (IBD), many of which have been previously implicated in other immune-related disorders, including ankylosing spondylitis and psoriasis.
Crohn’s disease (CD) and ulcerative colitis (UC) – inflammatory diseases of the gastrointestinal tract – have puzzled the scientific community for decades.
The new research centres on these two diseases, which are collectively known as inflammatory bowel disease (IBD) and suggests a fundamental connection between risk of IBD and genes involved in other immune-related diseases and the immune system’s response to pathogens.
Researchers from the Broad Institute, Massachusetts General Hospital, Yale School of Medicine, Cedars-Sinai Medical Center, and dozens of other organizations work together in the study.
“This study marks the first time we’ve acquired and combined the raw data from so many research studies around the world and also the first time we’ve jointly analyzed Crohn’s with ulcerative colitis,” said author Mark Daly, one of the senior authors of the work and senior associate member of the Broad Institute and co-director of its Program in Medical and Population Genetics.
“We’ve been able, with this study, to evaluate the evidence for both diseases simultaneously, and discovered that the majority of genetic risk factors are associated with both diseases,” he stated.
Co-author Ramnik Xavier, a senior associate member of the Broad Institute, Chief of Gastroenterology and Director of the Center for the Study of Inflammatory Bowel Disease at MGH said, “There’s been a paradigm shift in our understanding of IBD. This gene discovery process offers an opportunity to begin identifying new targets for treatment, better diagnostic tools, and in the long-term, personalized care for patients.”
“We now have the necessary starting material to understand the pathways that contribute to Crohn’s disease and ulcerative colitis, and we also have a framework to better appreciate that they may not be two distinct diseases, but rather collections of many different diseases,” he added.
The new study not only brings together the original data from those previous analyses, but also adds genetic information from another 40,000 people either with or without a form of IBD.
It also suggests a strong overlap between IBD susceptibility genes and genes tied to the immune system’s response to mycobacterial infections, including tuberculosis and leprosy.
Researchers have observed similarities between the immune response in CD and that seen in tuberculosis and hypothesize that CD could be an aberrant response to certain harmless organisms present in the gut that trigger a similar reaction.
In addition to drawing upon original data from previous studies, the work utilizes a relatively new tool known as the immunochip, which samples 200,000 sites in the genome previously tied to autoimmune and inflammatory diseases.
“As a research community, we designed this array to target genes involved in immune-mediated diseases of all kinds. This is one of our first studies using the immunochip, and there are many more results that will emerge from these studies within IBD and across immune diseases,” said Daly.
At the Broad Institute, researchers are already pursuing some of the pathways identified in previous studies of UC and CD, including autophagy, a process in which infected cells eat themselves to combat microbes.
“This work gives us additional leads to pursue. It gives us an opportunity for high-quality, translational research, allowing us to identify core pathways involved in IBD and better understand how genes interact with each other and with the environment, illuminating new pathways that contribute to disease,” said Xavier.