Tag Archives: leading cause of death

Parkinson’s and melanoma

A study has shown that people with Parkinson’s disease run a significantly higher risk of melanoma, which can be termed as the most dangerous type of skin cancer and the leading cause of death from skin diseases.

“Past studies linking Parkinson”s disease and melanoma have not been conclusive, so we wanted to explore a larger group of studies to see whether the link was consistent,” said study author Honglei Chen, MD, PhD, with the National Institute of Environmental Health Sciences, a division of the National Institutes of Health in Research Triangle Park, N.C., and a member of the American Academy of Neurology.

The researchers analyzed 12 studies conducted from 1965 and 2010 that looked at the possible relation between Parkinson’s disease and melanoma and found that most of the studies had fewer than 10 cases with both conditions.

Parkinson's disease

Parkinson's disease

They found that men with Parkinson’s disease run the risk two times than those without Parkinson’s to have melanoma. Women with Parkinson”s disease were one-and-a-half times as likely to be diagnosed with the melanoma compared to women without Parkinson”s.


“Parkinson’s disease patients in general have a lower risk for cancer, smoking-related cancers in particular, but they may have a higher risk for melanoma. One possible explanation for the link between Parkinson”s and melanoma is that the two diseases may share some genetic or environmental risk factors,” Chen added.

The research was published in the June 7, 2011, print issue of Neurology.

Diabetes to double or triple in U.S. by 2050

Up to a third of U.S. adults could have diabetes by 2050 if Americans continue to gain weight and avoid exercise, the Centers for Disease Control and Prevention projected on Friday.

The numbers are certain to go up as the population gets older, but they will accelerate even more unless Americans change their behavior, the CDC said.

“We project that, over the next 40 years, the prevalence of total diabetes (diagnosed and undiagnosed) in the United States will increase from its current level of about one in 10 adults to between one in five and one in three adults in 2050,” the CDC’s James Boyle and colleagues wrote in their report.

“These are alarming numbers that show how critical it is to change the course of type-2 diabetes,” CDC diabetes expert Ann Albright said in a statement.

“Successful programs to improve lifestyle choices on healthy eating and physical activity must be made more widely available because the stakes are too high and the personal toll too devastating to fail.”

The CDC says about 24 million U.S. adults have diabetes now, most of them type-2 diabetes linked strongly with poor diet and lack of exercise.

Boyle’s team took census numbers and data on current diabetes cases to make models projecting a trend. No matter what, diabetes will become more common, they said.

“These projected increases are largely attributable to the aging of the U.S. population, increasing numbers of members of higher-risk minority groups in the population, and people with diabetes living longer,” they wrote.


Diabetes was the seventh-leading cause of death in the United States in 2007, and is the leading cause of new cases of blindness among adults under age 75, as well as kidney failure, and leg and foot amputations not caused by injury.

“Diabetes, costing the United States more than $174 billion per year in 2007, is expected to take an increasingly large financial toll in subsequent years,” Boyle’s team wrote.

Diabetes mellitus, often simply referred to as diabetes—is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).

type 2 diabetes

Type 2 diabetes

There are three main types of diabetes:

* Type 1 diabetes: results from the body’s failure to produce insulin, and presently requires the person to inject insulin. (Also referred to as insulin-dependent diabetes mellitus, IDDM for short, and juvenile diabetes.)
* Type 2 diabetes: results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency.
* Gestational diabetes: is when pregnant women, who have never had diabetes before, have a high blood glucose level during pregnancy. It may precede development of type 2 DM.

Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.