Tag Archives: low blood sugar

New type 2 diabetes drug on the way

A new drug is showing results which should eventually be good news for many of the two million-plus million people in this country who have type 2 diabetes. A Phase II study, carried out by a team at the University of Michigan Medical School, Michigan found that TAK-875, a new, oral drug improves the release of insulin in a glucose-dependant manner. This means that when blood sugar levels are normal, it has no effect on them.

This is important because it may be able to improve blood glucose control without risking hypoglycaemia – what happens when blood glucose falls too low, so patients don’t have enough energy to function properly. Symptoms include feeling hungry, shaking, sweating and trembling. You can counteract this by having something containing sugar such as cola or fruit juice.

The study, which was led by Charles Burant of the University of Michigan, involved 426 people with type 2 diabetes. None of the participants were able to control their blood sugar levels well enough through diet, exercise or metformin treatment. Around 300 of the participants had one to five doses of TAK-875, 62 had glimepiride (one of the sulphonylureas drugs that help to lower blood sugar), and 61 had a placebo.

“In view of the frequent hypoglycaemia after treatment with sulfonylureas, the low risk of hypoglycaemia after treatment with TAK-875 suggests that there may be therapeutic advantage of targeting FFAR1 in treating people with type 2 diabetes,” explain the researchers.

“We are truly excited about the potential of TAK-875 and are eager to conduct larger trials to find out how well this drug works, how safe it is, and what its place is in the treatment of diabetes.”

Diabetes

Diabetes

Further work needs to be carried out, but so far the results appear promising. Reducing the risk of having to cope with the effects of low blood sugar could make a big difference to an awful lot of people.

The serious potential health risks associated with having diabetes this usually mean a change in lifestyle – eating a healthier diet, keeping to a healthy weight, and regular exercise as well as taking medication.


Look after your feet

Another study, published in the journal Diabetologia, found that people with diabetes are 20 times more likely to undergo an amputation. By comparing figures from Primary Care Trusts across England, the researchers also found a tenfold difference in amputation rates in different parts of England, varying from two amputations in every 10,000 people with diabetes, to 22 in every 10,000.

One of the researchers whop prepared the report, Professor William Jeffcoate, consultant diabetologist at Nottingham City Hospital, called for a more integrated approach to foot care. He said, “Foot disease is very complicated and a single professional hasn’t necessarily got the skills to manage every aspect of it.

“And that’s why I believe that only if you can gather a multi-disciplinary team and make sure that people have rapid access to assessment by such a team, it’s only in that way that we think you can provide the best service.”

Barbara Young, Chief Executive at Diabetes UK, said, “A single preventable amputation is one too many and so the fact that thousands of people in the UK are enduring unnecessary foot amputations is nothing short of a national disgrace.

“A big part of bringing this to an end is giving people with diabetes information about how to look after their feet, as many of them are not even aware that amputation is a potential complication. But we also need to make sure they understand what healthcare they should be getting. “

Type 2 diabetes

Between 1997 and 2003, there was a 74% rise in cases of diabetes in the UK – could you be next?

The basics

Your body works like any machine: it needs fuel to function, and sugar – or glucose, which is what sugar is converted to in your body – is what provides this energy. Diabetes occurs when your body is no longer able to manage the sugar from your diet.

Usually, you eat and glucose is filtered into the bloodstream where cells absorb it to grow or for energy. But in order for the cells to absorb the glucose, they need insulin, a hormone produced by your pancreas. Most people with type 2 diabetes have what is called ‘insulin resistance’. This means that although their pancreas produces enough insulin, the body doesn’t utilise it effectively. Glucose levels then rise in the blood and it is eventually flushed out via the kidneys and your urine. Raised blood glucose levels trigger a range of symptoms and can ultimately lead to complications including damage to eyesight, kidneys, circulation and peripheral nerves.

The risks

“Diabetes type 2 shortens your life expectancy by up to 10 years, with 80% of people with the disease dying from heart problems,” says Libby Dowling, care adviser for Diabetes UK. “We know there are around 2.5 million people with the disease – type 1 and 2 – and we estimate that at least 500,000 people unknowingly have type 2 diabetes”.

In the short term, diabetes’ effects – too much glucose in the bloodstream – will have an immediate impact on the body. High blood sugar (hyperglycemia) occurs when insulin levels are too low or aren’t effective, or from eating an excess of food. This causes the person to feel extremely thirsty, have dry skin, blurred vision and/or an overall feeling of drowsiness. If untreated, it can lead to heart problems and even coma.

Low blood sugar (hypoglycaemia) can occur if you are on medication and take too big a dose, if you do strenuous exercise without eating enough, drink alcohol on an empty stomach, or skip meals. The effects of too little glucose in your system are sweating, dizziness and the shakes. And if you do nothing to remedy the situation – by eating something like raisins or a glucose tablet, or drinking a glass of juice, for example – it can result in fainting or even coma.

Diabetes isn’t a death sentence, however, if it’s caught early and managed well, but if is left untreated, it will cause serious damage. Because it affects your body’s source of fuel, almost every body part could potentially be affected – diabetes can lead to blindness, heart disease, kidney failure, and even nerve damage resulting in the need for limb amputation.

Diabetes

Diabetes

The good news is that the test for diagnosing diabetes is simple: your blood glucose levels are checked either after a period of fasting or taking a glucose drink. Once diagnosed, you can adjust your lifestyle to lower your risks of further complications (see below), or if necessary, take regular medication to keep it in check.


The to-do list

Check your genes If a parent or sibling has type 2 diabetes, it puts you at increased risk of developing it too. See your GP for a test.

Cut your risk You can halve your risk of developing diabetes with the right diet and exercise, according to a study by the National Institutes of Health. And even if you already have diabetes, the correct diet can help keep it in check: “If you’ve been advised to lose weight, and depending on what you were eating before, many people can safely cut around 500 calories per day – though you must check with your doctor or diabetes clinic first,” says registered nutritionist Carina Norris.

Curb the simple carbs Because simple refined carbohydrates are broken down into glucose quickly they have the most dramatic – and potentially dangerous – effect on your blood sugar levels. Diabetes UK recommends limiting sugar, but says it’s okay to use it in foods and in baking as part of a healthy diet. Sugary drinks should be avoided, however, as they can cause blood sugar levels to spike.

Get sweaty If cutting back on your food is something you’d like to avoid at all costs, exercise. “If you up your physical activity, then you may not need to reduce your calorie intake as much,” says Norris. “Exercise actually increases your body’s sensitivity to insulin.” Running or doing an aerobics class will lower your blood sugar levels quickly so be prepared to eat something immediately afterward. Lifting weights, however, will have an effect on your blood sugar hours later – so again, be prepared by making sure you’ve got fruit, juice or a cereal bar with you.

Know your numbers High blood pressure is associated with diabetes – as are high cholesterol levels. Keep these in check by eating heart-healthy foods, keeping salt intake low and avoiding stress, if possible.

Keep tabs on it If you are at risk of diabetes or have been diagnosed with it, you can check your blood sugar levels using a glucose meter at home. Normal blood glucose levels should be between 4 to 8mmol/L, depending on how recently you have eaten – you can expect them to be raised after a meal and lower in the morning before breakfast.

Make the call Book an appointment to see your GP if you experience fatigue, a frequent need to pee, thirst, weight loss, blurry vision and/or wounds that are slow to heal. It is possible to have diabetes without any symptoms, however, so if you think you are at risk, ask for a test.