Tag Archives: Lymphatic system

Know your breasts – Part 1

Understanding the normal development and ageing process of your breasts will help you to notice any changes that are unusual for you.

Your breasts

The breasts (mammary glands) are a pair of glandular organs that produce milk in response to the hormonal changes of childbirth. They’re mainly made up of fatty tissue, which starts high on the front of the chest and extends down and around into the armpit. They are supported by ligaments and large muscles.

Each breast has 15 to 20 lobes with a number of lobules and ducts surrounded by fatty and supportive tissue. Each lobule has about 30 major ducts that open onto the nipple. The darker area of skin around the nipple is called the areola. At the edge of the areola there are large glands that produce fluid to lubricate the nipple.

In each armpit there are about 20 to 30 lymph nodes (glands), which drain fluid from the breast. These form part of the lymphatic system that helps the body to fight infection.

It’s common and perfectly normal for one breast to be larger than the other. The nipples usually point forward, although they may look different on each breast. It’s not unusual for one or both nipples to be turned inwards (inverted). This can be present from birth or can happen when the breasts are developing. The nipples themselves are hairless, but some women have a few hairs around the areola.

Between 0.4 and 6 per cent of women have an extra breast or pair of breasts, although the tissue may not look like a breast and be misdiagnosed as lymphatic or cystic. These are usually in the lower armpit and are known as accessory breasts. Some women have an extra nipple or nipples. These are usually below the breast or above the belly button on an imaginary line between the normal nipples and the groins. Accessory breasts and extra nipples aren’t usually a problem and don’t need to be removed.

Breast development

The breasts are constantly changing from puberty, through adolescence and the childbearing years and into the menopause, affected by changing levels in the female hormone oestrogen.

For most girls, breasts start to develop around the age of nine to 11, but it can be earlier or later. It’s not unusual for the breasts to grow at different rates. Breast lumps can occur while the breasts are developing. These are always benign and don’t usually need any treatment once they’ve been diagnosed.

Once the breasts have developed, changes linked to the monthly menstrual cycle (cyclical breast changes) are common. Just before a period, your breasts may become larger, tender or feel a bit lumpy. After a period, this lumpiness becomes less obvious or may disappear altogether (although some women may have tender, lumpy breasts all the time). Many women also experience breast pain linked to their menstrual cycle (cyclical breast pain).

Breast cancer

Breast cancer

During pregnancy, the breasts get much larger as the number of milk-producing cells increases. The nipples become darker and may remain that way after you’ve given birth, the areaolae may darken and develop small bumps too.

Around the menopause lumps are common. These often turn out to be breast cysts (benign fluid-filled sacs).


Breast tissue also changes with age. It begins to lose its firmness and the milk-producing tissue is replaced by fat, making the breasts sag. This is more noticeable after the menopause, when oestrogen levels fall. As you grow older, your breasts may change size too. If you take HRT (hormone replacement therapy) your breasts may feel firmer and sometimes quite tender.

Being breast aware

Every woman should be breast aware throughout her adult life. It’s an important part of caring for your body. It means knowing how your breasts look and feel normally, so you notice any changes that might be unusual for you.

Get into the habit of looking at and feeling your breasts from time to time. There is no set way to do this. You can decide what you’re comfortable with and when it’s convenient for you. You don’t have to look and feel at the same time.

What to look for

You need to be aware of any changes that are new or different, such as:

*A change in size – one breast may become noticeably larger or lower

*A nipple that has become inverted (pulled in) or changed its position or shape

*A rash on or around the nipple

*Discharge from one or both nipples

*Puckering or dimpling of the skin

*A swelling under your armpit or around your collarbone (where the lymph nodes are)

*A lump or thickening in your breast that feels different from the rest of the breast tissue.

*Constant pain in one part of your breast or armpit

What to do if you find a change

See your GP as soon as possible. Don’t worry that you may be making an unnecessary fuss and remember most breast changes aren’t cancer, even if they do need treatment or a follow-up.

When your GP examines your breasts he or she may be able to reassure you that there’s nothing to worry about. If the change may be connected with your hormones, your GP may ask you to come back at a different time in your menstrual cycle. Alternatively, he or she may decide to send you to a breast clinic for a more detailed examination.

Breast Cancer Care has more information about what happens at a breast clinic and the tests used to make a diagnosis.

New genes linked to colon cancer

Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité – University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases. In the future, their findings may help identify patients with aggressive tumors at an earlier stage.

The National Cancer Institute estimates that, alone in the United States, 106,100 cases of colon cancer will occur and 49,920 patients will die both from colon and rectal cancer in 2009.

Beginning in glands in the bowel lining, colorectal cancer often remains undiscovered initially. “However, the main problem is not the primary tumor,” explained the surgeon and clinical researcher Dr. Johannes Fritzmann, “but the dangerous metastases.”

Colon cancer

Colon cancer

Metastases arise when single cells break off from the primary tumor and spread to other body regions via the blood vessels or the lymphatic system. In colorectal cancer, these cells usually settle in the liver, lungs, or lymph nodes. Since the affected patient seldom feels pain or shows other symptoms, the tumor is frequently not discovered until it has already formed metastases.

To investigate which genetic mutations favor the formation of metastases, the researchers analyzed 150 tissue samples of colorectal cancer patients with and without metastases. The researchers identified 115 genes that are falsely regulated in both the primary tumors and their metastases. In this way, the researchers succeeded in identifying a genetic signature which distinguishes tumors with metastatic potential from those that do not metastasize.


Of the 115 genes the researchers identified, they focused on one gene in particular: BAMBI. They discovered that this gene is more active in metastatic tumors and metastases than in non-metastatic tumors.

“Our investigations show that the particular gene BAMBI is associated with two import signaling pathways and thus promotes metastasis formation,” Dr. Fritzmann said. “These signaling pathways (Wnt and TGF-beta) are, among other things, important in the developing embryo.”

In the future the researchers want to investigate the role of the other 114 genes more closely, in order to better understand the individual steps of metastasis formation.

Dr. Fritzmann hopes the research findings will help determine early on whether a tumor has metastatic potential. The doctors could then adapt the therapy accordingly.