A study has found more evidence supporting the role of fat around the heart in promoting atherosclerosis.
New results from the Multi-Ethnic Study of Atherosclerosis (MESA) has showed that pericardial fat is more strongly related to coronary artery plaque than either body mass index (BMI) or waist circumference.
When plaque forms in the arteries, it deposits in an irregular manner, causing thickening of the artery wall on one side, but not the other. The ratio of the thick side to the thin side is referred to as plaque eccentricity and is a strong indicator of heart disease.
While previous studies have looked at the relationship of pericardial fat to atherosclerosis in patients with severe coronary disease, this is the first study to determine the association of pericardial fat on coronary artery plaque burden in asymptomatic individuals.
“The individuals in this study had no symptoms and were otherwise healthy,” said senior author David A. Bluemke, M.D., Ph.D., director of Radiology and Imaging Sciences at the National Institutes of Health (NIH) Clinical Care.
“They did not have significant coronary artery narrowing. Yet, despite this, they had coronary plaque that could be detected by MRI,” added Bluemke.
For the study, 183 individuals without clinical cardiovascular disease were recruited from the Baltimore and Chicago field centers of MESA, a study funded by the NIH.
“Pericardial fat is located behind the sternum, around the heart, and we cannot see it except with CT or MRI,” said Bluemke.
“In some people, extra fat forms preferentially in this area. We do not know why. However, extra fat around the heart is generally associated with being overweight or obese,” added Bluemke.
The results showed that pericardial fat volume correlated significantly with the degree of plaque eccentricity in both men and women. After adjustment for BMI, waist circumference, traditional risk factors, C-reactive protein level and coronary calcium content, the relationship between pericardial fat and plaque eccentricity remained significant in men, but not in women.
“The findings indicate yet another reason that obesity is bad for us,” said Bluemke.
“It is particularly bad when the fat forms around the heart, since the heart fat appears to further promote coronary artery plaque,” added Bluemke.
The study has been published online in the journal Radiology.