Tag Archives: plant compounds

What are antioxidants?

We’re always hearing how antioxidants can protect against disease by fighting free radicals. But what exactly are they and what can they do for you?

Antioxidants are agents our body uses to protect against cell damage caused by free radicals. These are molecules formed as a natural by-product of bodily functions such as breathing, burning glucose for energy and fighting infection. Free radicals can also be generated by external factors such as sunlight, radiation, smoking and pollution.

Free radical damage (oxidative stress) is linked to the natural process of ageing and to a host of diseases, which become more common as we get older. These include cancer, cataracts, heart disease and stroke, diabetes, arthritis and Alzheimer’s disease.

“People who have a high level of antioxidants in their diet have better skin, a better quality of life and stay healthier for longer,” says Catherine Collins, chief dietician at St George’s hospital.

Where to get your antioxidants

Fruit, vegetables and plant-based foods such as herbs and spices are the main sources of antioxidants. They include:

* Carotenoids These are plant compounds such as betacarotene and lycopene, which give orange, red, green and yellow fruits and vegetables their colour. Good sources include apricots, mangoes, passion fruit, carrots, red pepper, sweet potato and tomatoes.

* Vitamin C A key antioxidant found in leafy greens such as cabbage, spinach and kale as well as blackcurrants, kiwi fruit and peppers.

* Vitamin E A fat-soluble antioxidant needed for the formation of red blood cells. Sources include wheat germ, corn, nuts, seeds, olives, spinach, asparagus and other green leafy vegetables, vegetable oils.

Fruit and vegetables

Fruit and vegetables

* Selenium A mineral present in soil, selenium is needed to make up an important enzyme which prevents free radical damage. Good sources include cereals, meat and Brazil nuts.

* Phenolic compounds These are a large group of plant chemicals with antioxidant properties. They include flavonoids, such as quercetin, found in onions, apples, tea, red wine and chocolate; lignans, found in flax seed and other grains; curcumin, found in turmeric and mustard; tannins found in red and green tea and isoflavones found in soya milk, tofu and miso.


Putting a range of different coloured foods on your plate is one of the most effective ways to get the antioxidants you need, as is consuming a ‘Mediterranean’ diet.

Catherine Collins warns that taking isolated nutrients in supplement form may not have the same effect. And high doses may even do more harm than good.

US research carried out in 2004, for example, found that large doses of vitamin E (over 400 ius) actually increased the risk of dying. Other research has found that large amounts of betacarotene in supplement form increase the risk of lung cancer in smokers and people who have worked with asbestos.

The UK’s Food Standards Agency advises smokers and people heavily exposed to asbestos against taking supplemental betacarotene and the rest of us not to exceed 7mg as a supplement a day.

Says Catherine Collins. “You can’t just take the ingredients out and put them into supplements. It really is preferable to get your antioxidants in food.”

Flaxseeds may reduce breat cancer risk

Eating a diet rich in flaxseeds can help cut the risk of dying from breast cancer later in life by 40 per cent, a new study has claimed.

Researchers at the German Cancer Research Centre in Heidelberg found that foods including seeds, vegetables and wheat contain special plant compounds, called phytoestrogens, which kill off cancer cells and prevent secondary tumours by stopping the growth of new blood vessels.

Among the most important phytoestrogens are the lignans which are found abundantly in flaxseeds, the researchers said.

Once in the body, they said, these phytoestrogens attach to female sex hormone oestrogen and are though to help protect against cancer, the Daily Mail reported.

For their study, the researchers analysed blood samples of over 1,000 women diagnosed with premenopausal breast cancer over a three year period.

They found that women with higher levels of enterolactone in their blood had their mortality rate dramatically reduced by two fifths compared to women with the lowest levels of the same substance.

Flaxseed

Flaxseed

The results, published in Journal of Clinical Oncology, also showed that high levels of enterolactone also protected against the spread of cancer and secondary tumours.

The researchers claimed phytoestrogens helped curtail cancer both because of its hormonal properties, as well as by killing off cancer cells and preventing the growth of new blood vessels.

Professor Jenny Chang-Claude, who led the study, said: .

“We now have first clear evidence showing that lignans lower not only the risk of developing postmenopausal breast cancer, but also the mortality risk.


“The result was significant only for the group of tumours that have no receptor for the estrogen hormone (ER-negative tumors). This gives reason to suspect that enterolactone protects from cancer not only by its hormone-like effect.”

According to the researchers, the study also gave a clue as to why Asian women are less frequently affected by breast cancer. Their soy-rich diet contains large amounts of another type of phytoestrogens called isoflavones.

Professor Chang-Claude said past studies of cells and animals had already provided evidence suggesting that the substance also has an influence on cancer growth irrespective of oestrogen.

“Thus, it promotes cell death and inhibits sprouting of new blood vessels,” she said.

“By eating a diet that is rich in wholemeal products, seeds and vegetables, which is considered to be health-promoting anyway, everybody can take in enough lignans,” she added.