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Euro E. coli outbreak advice

An outbreak of E. coli linked to contaminated salad vegetables has caused at least 16 deaths and hundreds of infections in Germany, Sweden and other countries.

What is E coli?

E. coli is short for Escherichia coli. It is a type of bacteria present in the gut of humans and other animals. Most strains are harmless but some are able to produce a toxin that can cause symptoms such as severe cramps and diarrhoea.

What do we know about this outbreak?

The outbreak is causing severe infections, affecting the blood, kidneys and sometimes the central nervous system.

The condition – haemolytic uraemic syndrome – is an unusual complication of some types of E. coli as well as other infections.

Symptoms include bloody diarrhoea, kidney failure and epileptic fits.

The strain suspected is O104, which is rare.

E.coli

E.coli

Another serious strain – known as O157 – causes similar symptoms, and has been associated with E. coli outbreaks from the 1980s onward.

Where has it come from?

The source of this outbreak is believed to be contaminated salad vegetables.

Initial reports that cucumbers were the source of the bacteria have not been confirmed and other food sources are being sampled.

A whole host of foods have been linked with past E. coli outbreaks.

While E. coli infection is often caused by eating undercooked meat and eggs, there has been a recent rise in cases caused by fresh fruit and vegetables.

They include foods that are eaten raw or only lightly cooked, such as salads, fresh fruit and bean sprouts.

What is the health advice?

Until the cause is known, German officials are telling people to avoid eating raw tomatoes, cucumbers and leafy salad including lettuce, especially in the north of the country, until further notice.

The UK’s Health Protection Agency recommends travellers follow the same advice.

It says anyone returning from Germany with illness including bloody diarrhoea should seek urgent medical attention and mention their travel history.

There have been three cases in the UK – all in visiting German nationals.

The Food Standards Agency in the UK has issued general advice on the need to wash fruit and vegetables.

The agency says: “It’s a good idea to wash fruit and vegetables before you eat them to ensure that they are clean, and to help remove germs that might be on the outside.

“Peeling or cooking fruit and vegetables can also remove these germs.”

However, a Scottish expert said new research suggests washing alone may not be enough, as the bacteria may be inside the food.

E. coli bacteria

E. coli bacteria

Dr Nicola Holden of The James Hutton Institute said: “The bacteria are able to get from animal sources on to crops through different routes, most likely in irrigation water or sometimes from slurry spraying, while some contamination can also occur during processing and packaging.”

She said the bacteria can colonise plant roots, moving up to the edible foliage or fruits.

“The threat to human health occurs because these bacteria are not simply sitting on the surface of the plant and are particularly difficult to remove post-harvest,” she added.


What do other experts say?

Professor Brendan Wren from the London School of Hygiene & Tropical Medicine said E. coli can attach to the surface of fresh produce such as lettuce leaves, spinach leaves and cucumber.

“These type of E.coli survive harsher environmental conditions than the typical E. coli and produce some nasty toxins to humans,” he said.

“They can survive in soil environments and fertiliser may be one source for the origin of the outbreak related to fresh produce such as cucumbers.”

Dr Jonathan Fletcher, senior lecturer in microbiology at the University of Bradford, said toxin-producing E. coli can cause very serious disease in humans, especially in the elderly or very young.

Cattle seem to carry the toxin in their gut, without showing signs of illness, and it will be shed in the faeces.

“If cattle manure is used as a fertiliser, it is probable that vegetables such as cucumbers will be contaminated with E. coli, and if not washed properly it would be present in sufficient numbers to cause the infection.”

Folic Acid may protect offspring from colon cancer

Folic acid supplements given to pregnant and breast-feeding rats reduced the rate of colon cancer in their offspring by 64 per cent, a new study has found.

The research, led by Dr. Young-in Kim, a gastroenterologist at St. Michael’s Hospital, adds to the growing but sometimes contradictory evidence that folic acid supplementation during pregnancy and lactation can increase or decrease the development or progression of some pediatric malignancies and common cancers in their offspring in adulthood.

For example, a separate study by Kim published in February found the daughters of rats who were given folic acid supplements before conception, during pregnancy and while breast-feeding have breast cancer rates twice as high as other rats who were not given the supplements. They also had more tumours and developed them at a faster rate.

Folic Acid

Folic Acid

Kim said these studies collectively suggest that folic acid may have drastically different effects on cancer development in different organs, that specific organs may have different needs for folate, its natural form, or metabolize it differently. He said more studies, including human studies, were needed.

Kim’s new study, published in Gut, an international journal in gastroenterology, is the first to find that folic acid supplements at the level ingested by North American women of childbearing age “significantly protects against the development of colorectal cancer in the offspring.”

Folate is known to help make DNA and help it replicate.


“It appears that giving folic acid during pregnancy and lactation reduces DNA damage and suppresses the proliferation of cells in the colon,” Kim said. “It actually increases the stability of the DNA and this might be one of the mechanisms of how folic acid in utero may protect against colon cancer.”

The amount of folic acid to which fetuses are exposed has increased dramatically in North America in the past decade. Natural folate is found in grains and dark, leafy vegetables. Women are routinely advised to take folic acid supplements before becoming pregnant and while pregnant to prevent neural tube birth defects such as spina bifida.

Since 1998, the Canadian and U.S. governments have required food manufacturers to add folic acid to white flour, enriched pasta and cornmeal products as a way of ensuring women receive enough of the B vitamin. In addition, up to 40 per cent of North Americans take folic acid supplements for possible but as yet unproven health benefits.