Tag Archives: ssris

Prozac dangers

Taking happy pills before driving makes you more prone to accidents, researchers claim.

They have found that taking common antidepressants such as Prozac and Seroxat heightens the risk by 70 per cent.

Even patients who have only been on the pills for a few hours are far more likely to have a crash if they get behind the wheel.

Although some manufacturers put warning notices on boxes telling patients their judgment may be impaired, they don’t specifically tell them not to drive.

But it is now thought that the same chemical changes that improve mood among those who take the pills also slows down reaction times.

Researchers say the study shows that doctors should be banning patients from getting behind the wheel as soon as they put them on a course of drugs.

Recently the number prescriptions for antidepressants have soared and last year nearly 50 million were handed out, a rise of a quarter in four years.

Campaigners have blamed the economic woes but also say GPs have become better at diagnosing the illness so are more likely to hand out the pills.

Prozac

Prozac

Researchers from the University of Taiwan looked at data on 36,000 and compared the likelihood of them having an accident to whether they were on antidepressants.

They also looked at other drugs including sleeping pills and antipsychotics which are taken for mental illnesses as well as dementia.

Collectively all of these drugs are known as psychotropic medication which means they affect mental activity or behaviour.


Those taking a common group of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) which include Prozac and Seroxat were 72 per cent more at risk.

Even patients who had only started the course of drugs that day were 74 per cent more likely to have an accident within 24 hours than those not on medication.

Those on a type of sleeping pills called benzodiazepines were 56 per cent more at risk of accidents while antipsychotics increased the likelihood by just 9 per cent.

Lead researcher Hui-Ju Tsai, who is based at the National Health Research Institutes in Zhunan, Taiwan, said: ‘ Our findings underscore that people taking these psychotropic drugs should pay increased attention to their driving performance in order to prevent motor vehicle accidents.

‘Doctors and pharmacists should choose safer treatments, provide their patients with accurate information and consider advising them not to drive while taking certain psychotropic medications.’

Know your antidepressants

There are several different kinds of anti-depressant medications which work in different ways.

If you have moderate to severe depression, or mild depression that has gone on for a long time, your GP may prescribe antidepressants. They’re thought to work by boosting the activity of chemicals in our brains, known as neurotransmitters, which send signals from cell to cell.

If you are over 65, you’ll find that your GP will adjust your prescription to take your age into account. This will usually be half the standard dose prescribed for most antidepressants.

Serotonin reuptake inhibitors (SSRIs)

These are the newest type of anti-depressants, (and the subjects of the report on antidepressants LINK), and the ones that are usually prescribed first. They stop a chemical in the brain, serotonin, (a neurotransmitter) being absorbed back into the cells that released it, so allowing it to work for longer. Low serotonin levels are thought to be a factor in depression.

However, these antidepressants do have side effects, including anxiety, trouble sleeping, restlessness, nausea, headaches and reduced sex drive. Most people only have a few of these side effects, and they may go away as your body becomes used to the drug, but, generally, as we get older, we can become more prone to side effects.

SSRIs include Fluoxetine (Prozac) and Paroxetene (Seroxat).

Tricyclic anti-depressants

Tricyclic anti-depressants

Tricyclic Antidepressants (TCAs)

TCAs work by raising the levels of neurotransmitters serotonin and noradrenaline. However TCAs tend to have more side effects such as a dry mouth and constipation and can make you drowsy and reduce your blood pressure, making you more prone to falls.

Your GP will usually prescribe SSRIs before considering TCAs. If you are taking TCAs, it’s dangerous to take more than your prescribed dose. And you shouldn’t take them if you’ve recently had a heart attack or are at risk of irregular heart beat (serious cardiac arrhythmias).

TCAs include amitriptyline, imipramine and nortriptyline.


Monoamine Oxidase Inhibitors (MAOIs)

These antidepressants also affect the levels of serotonin and noradrenaline in the brain, stopping them from being broken down. MAOIs are normally only prescribed if SSRIs and TCAs have failed to work, and aren’t really suitable for older people.

MAOIs include phenelzine, and isocarboxacid.

Serotonin-Norepinephrine Reuptake Inhibitors (SSNIs)

These are quite a new type of antidepressant, which have a similar effect to TCAs. However they can cause side effects, including an increase in blood pressure, so may not be suitable for everyone.

SSNIs include venlafaxine, nefazodone and mirtazapine.

Severe depression

There are a number of treatments that are only prescribed for people with severe depression. These include:

*Lithium carbonate and lithium citrate. You’ll normally only be prescribed this medication if other antidepressants haven’t worked for you. You need to take it alongside your existing treatment, and would need to have regular blood tests to check that your lithium levels aren’t too high.

*Electro convulsive therapy (ECT): This is normally only used if no other treatments have worked, and is not used often. It’s given in hospital, under a general anaesthetic, when a small electric current is passed through your brain. A course of treatment usually lasts from six to 12 sessions.