Tag Archives: treatment

Trial for stem cell treatment for damaged hearts

A simple injection of stem cells alongside usual treatments in heart attack patients could help limit the damage and prevent heart failure, researchers claim.

Scientists have been given the go-ahead for the first European trial of a new treatment that uses stem cells to improve blood supply to reduce the harm to the heart after an attack.

Revascor, a treatment incorporating stem cells from fit, young adults, is injected into the heart within 12 hours of a heart attack alongside usual procedures which aim to open up the arteries and restore blood flow.

Early trials on sheep suggest the new method can improve blood flow to damaged tissue, limit scarring and improve heart function.

Stem cells

Stem cells

This could help cut the risk of heart failure, which occurs when the blood becomes less efficient at pumping blood around the body and is often prompted by damage sustained in heart attacks.

A 225 patient trial, which will be conducted in Britain and other European countries, will aim to establish if the treatment is effective in humans.


Professor Eric Duckers, the lead investigator from Erasmus University Hospital in The Netherlands, said: “We are excited to be pioneering a novel and minimally invasive clinical approach that has the potential to greatly improve the quality of life for patients suffering acute heart attacks.”

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said: “This experimental trial takes another step towards knowing whether cell therapy will be able to help repair damaged hearts safely.

“However, we are still a long way from knowing whether this particular therapy will succeed or whether other ways to encourage damaged heart tissue to repair will be more successful.”

Virus used to kill cancer cells

A virus that hunts down and treats cancer has been used in patients for the first time, with encouraging results.

Canadian doctors found an intravenous injection allowed the virus to spread through the bloodstream and infect tumour cells anywhere in the body.

Healthy tissue was unharmed.

The ground-breaking trial was intended to test only safety.

But in six of the eight patients given the highest doses, the tumours shrank or stopped growing.

Professor John Bell, of The Ottawa Hospital Research Institute, said: “We are very excited because this is the first time in medical history that a viral therapy has been shown to consistently and selectively replicate in cancer tissue.”

Cancer cells

Cancer cells

The JX-594 virus was derived from a strain used in the smallpox vaccine. It was engineered to enhance its anti-cancer properties.

The 23 patients in the trial had a range of advanced cancers that had stopped responding to existing treatments.

They were given a one-off infusion of the virus. Some suffered flu-like symptoms, but the treatment was otherwise well-tolerated.

The trial is reported in the journal Nature and further studies are now planned.


Professor Nick Lemoine, of Cancer Research UK, said the treatment showed “real promise”.

“This new study is important because it shows that a virus previously used safely to vaccinate against smallpox can now be modified to reach cancers through the bloodstream – even after cancer has spread widely through the patient’s body.

“It is particularly encouraging that responses were seen even in tumours such as mesothelioma, a cancer which can be particularly hard to treat.”